ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Repression of the calcitonin gene-related peptide promoter by 5-HT1 receptor activation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
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- Method for cryopreservation of trigeminal ganglion for establishing primary cultures of neurons and glia.Journal of neuroscience methods · 2024Article
- The 5-HTNature reviews. Neurology · 2023Review
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Neurogenic inflammation and its role in migraine.Seminars in immunopathology · 2018Review
- Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Serotonin and CGRP in migraine.Annals of neurosciences · 2012Review
- Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?The journal of headache and pain · 2011Article
- Pharmacology.Handbook of clinical neurology · 2010Article
- CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways.Journal of neurochemistry · 2009Article
- Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.Molecular pain · 2008Article
- Nitric oxide regulation of calcitonin gene-related peptide gene expression in rat trigeminal ganglia neurons.The European journal of neuroscience · 2006Article
- Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches.Drugs · 2005Review
- cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Stimulation of the calcitonin gene-related peptide enhancer by mitogen-activated protein kinases and repression by an antimigraine drug in trigeminal ganglia neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Regulation of calcitonin gene-related peptide secretion by a serotonergic antimigraine drug.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Thyroid transcription factor 1 is calcium modulated and coordinately regulates genes involved in calcium homeostasis in C cells.Molecular and cellular biology · 1998Article
- Understanding migraine: Potential role of neurogenic inflammation.Annals of Indian Academy of NeurologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated the control of calcitonin gene-related peptide (CGRP) expression by a serotonergic agonist that is related pharmacologically to currently used antimigraine drugs. During migraines, CGRP levels are elevated but then returned to normal by a 5-HT1 receptor agonist, sumatriptan. However, neither the molecular nor cellular targets of this drug are known. Trigeminal neurons are the major source of cerebrovascular CGRP, and thus we have used trigeminal primary cultures and the neuronal-like CA77 thyroid C-cell line as a model. We first demonstrate that sumatriptan and another 5-HT1 agonist, CGS 12066A (CGS), cause a robust and prolonged increase with oscillations in intracellular calcium in CA77 cells. CGS caused a similar increase in trigeminal cultures. We then show that CGS treatment leads to a decrease in CGRP mRNA levels in the CA77 cells. This decrease is attributable to the repression of promoter activity through two discrete elements: (1) the cAMP-responsive region, via a cAMP-independent mechanism; and (2) the cell-specific enhancer, which binds the upstream stimulatory factor helix-loop-helix protein and a cell-specific activator. These results demonstrate that activation of the endogenous 5-HT1 receptor is coupled to calcium signaling pathways and leads to inhibition of CGRP gene transcription.
Indexed as
Identifiers
9391009PMC6573409W1588557655What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.