Evidence map›Paper›PMID 9390998›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997

Identification of two nervous system-specific members of the erg potassium channel gene family.

W Shi, R S Wymore, H S Wang, Z Pan, I S Cohen, D McKinnon, J E Dixon

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 214 citations in OpenAlex.

  1. Article
  2. Fentanyl blockade of KThe Journal of physiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Characteristics of A-type voltage-gated KCell and tissue research · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Cisapride induced hypoglycemiaFrontiers in endocrinology · 2022
    Article
  15. The ERG1 KFrontiers in molecular neuroscience · 2022
    Review
  16. KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial CaOxidative medicine and cellular longevity · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Ion Channels of the Islets in Type 2 Diabetes.Journal of molecular biology · 2020
    Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

W ShiDepartment of Neurobiology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.
R S Wymore
H S Wang
Z Pan
I S Cohen
D McKinnon
J E Dixon
State University of New York · USStony Brook University · US

Funding

THE BIOCHEMISTRY AND CELL BIOLOGY OF METABOLIC DISEASEST32DK007521 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI MALBON, CRAIG C · 1987 to 2012
$3.9M
Molecular Physiology--Control of Firing PropertiesR01NS029755 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI MCKINNON, DAVID · 1992 to 2004
$1.6M
CARDIAC ELECTROPHYSIOLOGY: EFFECTS OF IONS AND DRUGSR01HL020558 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI COHEN, IRA S · 1985 to 2003
$1.5M
TROPHIC CONTROL OF ELECTROPHYSIOLOGICAL PHENOTYPEK17NS001718 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI DIXON, JANE E · 1994 to 1997
–
CARDIAC ELECTROPHYSIOLOGY: EFFECTS OF IONS &DRUGSR37HL020558 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI COHEN, IRA S · 1990 to 1999
–
NHLBI NIH HHS HL-20558NHLBI NIH HHS R01 HL020558NHLBI NIH HHS R37 HL020558NIDDK NIH HHS T32 DK007521NINDS NIH HHS NS-01718NINDS NIH HHS NS-29755NINDS NIH HHS R01 NS029755
6 · The paper itself

Abstract

Two new potassium channel genes, erg2 and erg3, that are expressed in the nervous system of the rat were identified. These two genes form a small gene family with the previously described erg1 (HERG) gene. The erg2 and erg3 genes are expressed exclusively in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural tissues. All three genes are expressed in peripheral sympathetic ganglia. The erg3 channel produces a current that has a large transient component at positive potentials, whereas the other two channels are slowly activating delayed rectifiers. Expression of the erg1 gene in the sympathetic nervous system has potential implications for the etiology of the LQT2 form of the human genetic disease long QT syndrome.

Indexed as

Cation Transport ProteinsDNA-Binding ProteinsMembrane Transport ProteinsPotassium Channels, Voltage-GatedTrans-ActivatorsAnimalsCloning, MolecularDNA, ComplementaryElectrophysiologyERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsGene ExpressionHeartHumansKineticsLong QT SyndromeCation Transport ProteinsDNA-Binding ProteinsDNA, ComplementaryERG1 Potassium ChannelERG protein, humanEther-A-Go-Go Potassium ChannelsKCNH2 protein, humanKCNH6 protein, humanKcnh6 protein, ratKCNH7 protein, humanKcnh7 protein, ratMembrane Transport ProteinsPotassium ChannelsPotassium Channels, Voltage-GatedRNA, MessengerTrans-ActivatorsTranscriptional Regulator ERG

Identifiers

PMID9390998
PMCPMC6573403
OpenAlexW2127474777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.