ArticleGenes & development1997
The Arabidopsis GAI gene defines a signaling pathway that negatively regulates gibberellin responses.
Article in Genes & development, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 482 papers.
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Who cites it
482 citing papers in PubMed.
- Synthetic activation of gibberellin signalling reveals spatial coordination of root growth.Nature plants · 2026Article
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
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- Metabolo-Transcriptomic Analysis Reveals the Mechanisms Underlying Seed Dormancy Release inInternational journal of molecular sciences · 2026Article
- Touch-Responsive CsaGASAs Regulate Tendril Length During the Climbing Stage in Cucumber.Plant, cell & environment · 2026Article
- The transcription elongation factor IWS1 promotes thermomorphogenesis by integrating the brassinosteroid and gibberellin pathways in Arabidopsis.Plant communications · 2026Article
- Structure-guided reprogramming of DELLA turnover for a sustainable Green Revolution in rice.Nature communications · 2026Article
- Insights into the functional and genetic basis of heteranthery in Arthrostemma ciliatum Pav. ex D.Don (Melastomataceae).BMC plant biology · 2026Article
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.bioRxiv : the preprint server for biology · 2026Article
- A Single-Base Mutation in TaWAK3-B Reduces Plant Height via Cytoskeleton in Bread Wheat.Plant biotechnology journal · 2026Article
- AtGASA1 positively regulates Arabidopsis response to salt stress by suppressing accumulation of reactive oxygen species.Plant cell reports · 2026Article
- CRK2 modulates flowering in Arabidopsis together with GLYCINE-RICH RNA-BINDING PROTEIN 7.The New phytologist · 2026Article
- Membrane-associated DELLA degradation modulates growth under carbon/nitrogen imbalance.The Plant cell · 2026Article
- Identification and characterization of GRAS transcription factors inFrontiers in plant science · 2026Article
- Genome-Wide Association Analysis of Soybean Regeneration-Related Traits and Functional Exploration of Candidate Genes.Plants (Basel, Switzerland) · 2025Article
- ROS-mediated interplay between brassinosteroids and gibberellic acids antagonistically modulates asymmetric periclinal cell division leading to middle cortex formation inPlant signaling & behavior · 2025Article
- Article
- Identification and characterization of ninePlant signaling & behavior · 2025Article
- Seasons and shape: inflorescences from autumn to summer.Journal of experimental botany · 2025Review
422 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
The Arabidopsis gai mutant allele confers a reduction in gibberellin (GA) responsiveness. Here we report the molecular cloning of GAI and a closely related gene GRS. The predicted GAI (wild-type) and gai (mutant) proteins differ only by the deletion of a 17-amino-acid segment from within the amino-terminal region. GAI and GRS contain nuclear localization signals, a region of homology to a putative transcription factor, and motifs characteristic of transcriptional coactivators. Genetic analysis indicates that GAI is a repressor of GA responses, that GA can release this repression, and that gai is a mutant repressor that is relatively resistant to the effects of GA. Mutations at SPY and GAR2 suppress the gai phenotype, indicating the involvement of GAI, SPY, and GAR2 in a signaling pathway that regulates GA responses negatively. The existence of this pathway suggests that GA modulates plant growth through derepression rather than through simple stimulation.
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