ArticleThe EMBO journal1997
Control of B cell development by Ras-mediated activation of Raf.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 146 citations in OpenAlex.
- A progeria syndrome links DNA hypermethylation to age-related pathology.Nature genetics · 2026Article
- Azanucleoside treatment leads to B-cell precursor acute lymphoblastic leukemia.Blood neoplasia · 2025Article
- The function of serine/threonine-specific protein kinases in B cells.Frontiers in immunology · 2024Review
- A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer.International journal of molecular sciences · 2023Review
- TRIP13 modulates protein deubiquitination and accelerates tumor development and progression of B cell malignancies.The Journal of clinical investigation · 2021Article
- RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils.Frontiers in immunology · 2021Article
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- Multifaceted effects of soluble human CD6 in experimental cancer models.Journal for immunotherapy of cancer · 2020Article
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- Inflammatory immune cells may impair the preBCR checkpoint, reduce new B cell production, and alter the antibody repertoire in old age.Experimental gerontology · 2018Review
- Developmental stage-specific effects of Pim-1 dysregulation on murine bone marrow B cell development.BMC immunology · 2016Article
- Kras Is Critical for B Cell Lymphopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Review
- NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.Cell communication and signaling : CCS · 2014Article
- Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling.Nature reviews. Immunology · 2014Review
- Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.Molecular and cellular biology · 2013Article
- New insights into pre-BCR and BCR signalling with relevance to B cell malignancies.Nature reviews. Immunology · 2013Review
- Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire.Immunologic research · 2013Review
- Article
- Hematopoietic protein-1 regulates the actin membrane skeleton and membrane stability in murine erythrocytes.PloS one · 2013Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cell fate commitment in a variety of lineages requires signals conveyed via p21ras. To examine the role of p21ras in the development of B lymphocytes, we generated transgenic mice expressing a dominant-negative form of Ras in B lymphocyte progenitors, using a novel transcriptional element consisting of the Emu enhancer and the lck proximal promoter. Expression of dominant-negative Ras arrests B cell development at a very early stage, prior to formation of the pre-B cell receptor. Furthermore, an activated form of Raf expressed in the same experimental system could both drive the maturation of normal pro-B cells and rescue development of progenitors expressing dominant-negative Ras. Hence p21ras normally regulates early development of B lymphocytes by a mechanism that involves activation of the serine/threonine kinase Raf.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.