ArticleThe EMBO journal1997
Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 133 citations in OpenAlex.
- Clinical validity of congenital myopathy genes determined by the ClinGen Congenital Myopathies Expert Panel.Journal of neuromuscular diseases · 2025Article
- RyR1 Is Involved in the Control of Myogenesis.Cells · 2025Article
- ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.Developmental cell · 2021Article
- Ion Channel Gene Mutations Causing Skeletal Muscle Disorders: Pathomechanisms and Opportunities for Therapy.Cells · 2021Review
- Caffeine as a tool to investigate sarcoplasmic reticulum and intracellular calcium dynamics in human skeletal muscles.Journal of muscle research and cell motility · 2021Review
- Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.Molecules (Basel, Switzerland) · 2020Review
- Update on Congenital Myopathies in Adulthood.International journal of molecular sciences · 2020Review
- Elementary calcium signaling in arterial smooth muscle.Channels (Austin, Tex.) · 2019Review
- The Genomics of Arthrogryposis, a Complex Trait: Candidate Genes and Further Evidence for Oligogenic Inheritance.American journal of human genetics · 2019Article
- Extraocular muscle function is impaired inThe Journal of general physiology · 2019Article
- It's time to look more closely at RYR3.The Journal of general physiology · 2019Article
- Junctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain.The Journal of general physiology · 2018Article
- The BMP2 nuclear variant, nBMP2, is expressed in mouse hippocampus and impacts memory.Scientific reports · 2017Article
- Article
- Differential effects of contractile potentiators on action potential-induced CaJournal of muscle research and cell motility · 2016Article
- The disorders of the calcium release unit of skeletal muscles: what have we learned from mouse models?Journal of muscle research and cell motility · 2015Review
- The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease.Channels (Austin, Tex.) · 2014Article
- Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development.BMC research notes · 2011Article
- Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.Experimental eye research · 2011Article
- Bivariate association analysis in selected samples: application to a GWAS of two bone mineral density phenotypes in males with high or low BMD.European journal of human genetics : EJHG · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The skeletal isoform of Ca2+ release channel, RyR1, plays a central role in activation of skeletal muscle contraction. Another isoform, RyR3, has been observed recently in some mammalian skeletal muscles, but whether it participates in regulating skeletal muscle contraction is not known. The expression of RyR3 in skeletal muscles was studied in mice from late fetal stages to adult life. RyR3 was found to be expressed widely in murine skeletal muscles during the post-natal phase of muscle development, but was not detectable in muscles of adult mice, with the exception of the diaphragm and soleus muscles. RyR3 knockout mice were generated, and it was shown that skeletal muscle contraction in these mice was impaired during the first weeks after birth. In skeletal muscles isolated from newborn RyR3(-/- )mice, but not in those from adult mice, the twitch elicited by electrical stimulation and the contracture induced by caffeine were strongly depressed. These results provide the first evidence that RyR3 has a physiological role in excitation-contraction coupling of neonatal skeletal muscles. The disproportion between the low amount of RyR3 and the large impact of the RyR3 knockout suggests that this isoform contributes to the amplification of Ca2+ released by the existing population of ryanodine receptors (RyR1).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.