ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 citing papers in PubMed, 43 citations in OpenAlex.
- Assessing the Cognitive Translational Potential of a Mouse Model of the 22q11.2 Microdeletion Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network.The EMBO journal · 2001Article
- Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Structure and chromosomal locations of mouse steroid receptor coactivator gene family.In vitro cellular & developmental biology. Animal · 1999Article
- Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene.Genome research · 1998Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have constructed a comparative map in mouse of the critical region of human 22q11 deleted in DiGeorge (DGS) and Velocardiofacial (VCFS) syndromes. The map includes 11 genes potentially haploinsufficient in these deletion syndromes. We have localized all the conserved genes to mouse Chromosome (Chr) 16, bands B1-B3. The determination of gene order shows the presence of two regions (distal and proximal), containing two groups of conserved genes. The gene order in the two regions is not completely conserved; only in the proximal group is the gene order identical to human. In the distal group the gene order is inverted. These two regions are separated by a DNA segment containing at least one gene which, in the human DGS region, is the most proximal of the known deleted genes. In addition, the gene order within the distal group of genes is inverted relative to the human gene order. Furthermore, a clathrin heavy chain-like gene was not found in the mouse genome by DNA hybridization, indicating that there is an inconsistent level of gene conservation in the region. These and other independent data obtained in our laboratory clearly show a complex evolutionary history of the DGS-VCFS region. Our data provide a framework for the development of a mouse model for the 22q11 deletion with chromosome engineering technologies.
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