ArticleGenetics1997
An approximate model of polygenic inheritance.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Homeobox B13 G84E Mutation and Prostate Cancer Risk.European urology · 2019Pooled it
- Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction.American journal of human genetics · 2022Article
- Inbreeding Coefficient and Distance in MHC Genes of Parents as Predictors of Reproductive Success in Domestic Cat.Animals : an open access journal from MDPI · 2022Article
- A New Comprehensive Colorectal Cancer Risk Prediction Model Incorporating Family History, Personal Characteristics, and Environmental Factors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Polygenic risk score is associated with increased disease risk in 52 Finnish breast cancer families.Breast cancer research and treatment · 2016Article
- Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas.Molecular genetics & genomic medicine · 2016Article
- Reflections on the Field of Human Genetics: A Call for Increased Disease Genetics Theory.Frontiers in genetics · 2016Article
- A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects.Journal of medical genetics · 2015Article
- Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer.British journal of cancer · 2013Article
- How can polygenic inheritance be used in population screening for common diseases?Genetics in medicine : official journal of the American College of Medical Genetics · 2013Review
- Population-based estimate of prostate cancer risk for carriers of the HOXB13 missense mutation G84E.PloS one · 2013Article
- A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact.Genetic epidemiology · 2011Article
- A segregation analysis of Barrett's esophagus and associated adenocarcinomas.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010Article
- Incorporating tumour pathology information into breast cancer risk prediction algorithms.Breast cancer research : BCR · 2010Article
- Linkage analysis of adult height in a large pedigree from a Dutch genetically isolated population.Human genetics · 2009Article
- A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes.British journal of cancer · 2002Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The finite polygenic model approximates polygenic inheritance by postulating that a quantitative trait is determined by n independent, additive loci. The 3n possible genotypes for each person in this model limit its applicability. CANNINGS, THOMPSON, and SKOLNICK suggested a simplified, nongenetic version of the model involving only 2n + 1 genotypes per person. This article shows that this hypergeometric polygenic model also approximates polygenic inheritance well. In particular, for noninbred pedigrees, trait means, variances, covariances, and marginal distributions match those of the ordinary finite polygenic model. Furthermore as n --> infinity, the trait values within a pedigree collectively tend toward multivariate normality. The implications of these results for likelihood evaluation under the polygenic threshold and mixed models of inheritance are discussed. Finally, a simple numerical example illustrates the application of the hypergeometric polygenic model to risk prediction under the polygenic threshold model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.