ArticleGenetics1997
DNA sequence analysis of Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL/6J-Y(POS) sex reversal and defines the SRY functional unit.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Developmental disorders of the reproductive tract in C57BL/6N-XYThe Journal of veterinary medical science · 2026Article
- Inefficient Sox9 upregulation and absence of Rspo1 repression lead to sex reversal in the B6.XYTIR mouse gonad†.Biology of reproduction · 2024Article
- Interaction between sex-determining genes from two species: clues fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads.The Journal of veterinary medical science · 2020Article
- Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13.Genetics · 2020Article
- Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YThe Journal of veterinary medical science · 2019Article
- Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal.Scientific reports · 2017Article
- Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XY(POS) mice.The Journal of veterinary medical science · 2016Article
- Effect of the Y chromosome on testis weight in mice.The Journal of veterinary medical science · 2015Article
- Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.Human molecular genetics · 2014Article
- Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.Genes & development · 2009Article
- New insights into SRY regulation through identification of 5' conserved sequences.BMC molecular biology · 2008Article
- The chromosome 11 region from strain 129 provides protection from sex reversal in XYPOS mice.Genetics · 2008Article
- Article
- C57BL/6J-T-associated sex reversal in mice is caused by reduced expression of a Mus domesticus Sry allele.Genetics · 2001Article
- Do lampreys have lymphocytes? The Spi evidence.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Genetic variation and phylogeography of central Asian and other house mice, including a major new mitochondrial lineage in Yemen.Genetics · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Sry (sex determining region, Y chromosome) open reading frame from mice representing four species of the genus Mus was sequenced in an effort to understand the conditional dysfunction of some M. domesticus Sry alleles when present on the C57BL/6J inbred strain genetic background and to delimit the functionally important protein regions. Twenty-two Sry alleles were sequenced, most from wild-derived Y chromosomes, including 11 M. domesticus alleles, seven M. musculus alleles and two alleles each from the related species M. spicilegus and M. spretus. We found that the HMG domain (high mobility group DNA binding domain) and the unique regions are well conserved, while the glutamine repeat cluster (GRC) region is quite variable. No correlation was found between the predicted protein isoforms and the ability of a Sry allele to allow differentiation of ovarian tissue when on the C57BL/6J genetic background, strongly suggesting that the cause of this sex reversal is not the Sry protein itself, but rather the regulation of SRY expression. Furthermore, our interspecies sequence analysis provides compelling evidence that the M. musculus and M. domesticus SRY functional domain is contained in the first 143 amino acids, which includes the HMG domain and adjacent unique region (UR-2).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.