ArticleGenetics1997
Comparable rates of gene loss and functional divergence after genome duplications early in vertebrate evolution.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 230 citations in OpenAlex.
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- Genome-wide analysis of the U-box E3 ubiquitin ligase enzyme gene family in tomato.Scientific reports · 2020Article
- The origin and diversification of a novel protein family in venomous snakes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Natural Selection Drives Rapid Functional Evolution of Young Drosophila Duplicate Genes.Molecular biology and evolution · 2017Article
- Duplication and Sub/Neofunctionalization ofG3 (Bethesda, Md.) · 2017Article
- Paralog analyses reveal gene duplication events and genes under positive selection in Ixodes scapularis and other ixodid ticks.BMC genomics · 2016Article
- Evolution by gene duplication of Medicago truncatula PISTILLATA-like transcription factors.Journal of experimental botany · 2016Article
- Functional diversification of vitamin D receptor paralogs in teleost fish after a whole genome duplication event.Endocrinology · 2014Article
- Genetic robustness and functional evolution of gene duplicates.Nucleic acids research · 2014Article
- Expression and evolution of the non-canonically translated yeast mitochondrial acetyl-CoA carboxylase Hfa1p.PloS one · 2014Article
- Neofunctionalization of young duplicate genes in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Ancient eudicot hexaploidy meets ancestral eurosid gene order.BMC genomics · 2013Article
- Contrasted patterns of selective pressure in three recent paralogous gene pairs in the Medicago genus (L.).BMC evolutionary biology · 2012Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Duplicated genes are an important source of new protein functions and novel developmental and physiological pathways. Whereas most models for fate of duplicated genes show that they tend to be rapidly lost, models for pathway evolution suggest that many duplicated genes rapidly acquire novel functions. Little empirical evidence is available, however, for the relative rates of gene loss vs. divergence to help resolve these contradictory expectations. Gene families resulting from genome duplications provide an opportunity to address this apparent contradiction. With genome duplication, the number of duplicated genes in a gene family is at most 2n, where n is the number of duplications. The size of each gene family, e.g., 1, 2, 3, ..., 2n, reflects the patterns of gene loss vs. functional divergence after duplication. We focused on gene families in humans and mice that arose from genome duplications in early vertebrate evolution and we analyzed the frequency distribution of gene family size, i.e., the number of families with two, three or four members. All the models that we evaluated showed that duplicated genes are almost as likely to acquire a new and essential function as to be lost through acquisition of mutations that compromise protein function. An explanation for the unexpectedly high rate of functional divergence is that duplication allows genes to accumulate more neutral than disadvantageous mutations, thereby providing more opportunities to acquire diversified functions and pathways.
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