ArticleGenetics1997
SRO9, a multicopy suppressor of the bud growth defect in the Saccharomyces cerevisiae rho3-deficient cells, shows strong genetic interactions with tropomyosin genes, suggesting its role in organization of the actin cytoskeleton.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Inducible chromosomal rearrangement reveals nonlinear polygenic dosage effects in driving aneuploid yeast traits.Nature communications · 2025Article
- Proteomic Analysis Revealed that DVL, a Lectin Purified fromACS omega · 2025Article
- The tomosyn homologue, Sro7, is a direct effector of the Rab GTPase, Sec4, in post-Golgi vesicle tethering.Molecular biology of the cell · 2018Article
- Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress.Eukaryotic cell · 2013Article
- La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast.RNA (New York, N.Y.) · 2012Article
- Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.Genetics · 2011Review
- Nucleocytoplasmic shuttling of the La motif-containing protein Sro9 might link its nuclear and cytoplasmic functions.RNA (New York, N.Y.) · 2010Article
- The role of PAS kinase in PASsing the glucose signal.Sensors (Basel, Switzerland) · 2010Review
- Regulation and function of yeast PAS kinase: a role in the maintenance of cellular integrity.Cell cycle (Georgetown, Tex.) · 2009Article
- C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis.RNA (New York, N.Y.) · 2008Article
- The yeast tumor suppressor homologue Sro7p is required for targeting of the sodium pumping ATPase to the cell surface.Molecular biology of the cell · 2006Article
- Cell wall integrity signaling in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2005Review
- Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast.The Journal of cell biology · 2003Article
- Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme.Molecular and cellular biology · 2001Article
- Multiple mechanisms of suppression circumvent transcription defects in an RNA polymerase mutant.Molecular and cellular biology · 2000Article
- The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.Molecular biology of the cell · 1999Article
- Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes.Molecular biology of the cell · 1999Article
- Article
- Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in function.Genetics · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RHO3 encodes a Rho-type small GTPase in the yeast Saccharomyces cerevisiae and is involved in the proper organization of the actin cytoskeleton required for bud growth. SRO9 (YCL37c) was isolated as a multicopy suppressor of a rho3delta mutation. An Sro9p domain required for function is similar to a domain in the La protein (an RNA-binding protein). Disruption of SRO9 did not affect vegetative growth, even with the simultaneous disruption of an SRO9 homologue, SRO99. However, sro9delta was synthetically lethal with a disruption of TPM1, which encodes tropomyosin; sro9delta tpm1delta cells did not distribute cortical actin patches properly and lysed. We isolated TPM2, the other gene for tropomyosin, as a multicopy suppressor of a tpm1delta sro9delta double mutant. Genetic analysis suggests that TPM2 is functionally related to TPM1 and that tropomyosin is important but not essential for cell growth. Overexpression of SRO9 suppressed the growth defect in tpm1delta tpm2delta cells, disappearance of cables of actin filaments in both rho3delta cells and tpm1delta cells, and temperature sensitivity of actin mutant cells (act1-1 cells), suggesting that Sro9p has a function that overlaps or is related to tropomyosin function. Unlike tropomyosin, Sro9p does not colocalize with actin cables but is diffusely cytoplasmic. These results suggest that Sro9p is a new cytoplasmic factor involved in the organization of actin filaments.
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