ArticleThe Journal of general physiology1997
Caffeine-induced release of intracellular Ca2+ from Chinese hamster ovary cells expressing skeletal muscle ryanodine receptor. Effects on full-length and carboxyl-terminal portion of Ca2+ release channels.
Article in The Journal of general physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Can 3 mg·kgNutrients · 2021Trial
- Caffeine-Induced Effects on Human Skeletal Muscle Contraction Time and Maximal Displacement Measured by Tensiomyography.Nutrients · 2021Trial
- Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling.The Journal of cell biology · 2014Trial
- Effects of Various Caffeine Doses on Cognitive Abilities in Female Athletes with Low Caffeine Consumption.Brain sciences · 2024Article
- Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function.Cardiovascular research · 2021Article
- TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle.Circulation research · 2020Article
- From synaptic input to muscle contraction: arm muscle cells of Octopus vulgaris show unique neuromuscular junction and excitation-contraction coupling properties.Proceedings. Biological sciences · 2019Article
- Is the Ergogenicity of Caffeine Affected by Increasing Age? The Direct Effect of a Physiological Concentration of Caffeine on the Power Output of Maximally Stimulated EDL and Diaphragm Muscle Isolated from the Mouse.The journal of nutrition, health & aging · 2017Article
- Spontaneous inward currents reflecting oscillatory activation of Na⁺/Ca²⁺ exchangers in human embryonic stem cell-derived cardiomyocytes.Pflugers Archiv : European journal of physiology · 2016Article
- What can isolated skeletal muscle experiments tell us about the effects of caffeine on exercise performance?British journal of pharmacology · 2015Review
- A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels.Journal of cell science · 2015Article
- Primary pathways of intracellular Ca(2+) mobilization by nanosecond pulsed electric field.Biochimica et biophysica acta · 2013Article
- Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation.Cell calcium · 2012Article
- Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2011Article
- A two-gate model for the ryanodine receptor with allosteric modulation by caffeine and quercetin.European biophysics journal : EBJ · 2008Article
- Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit.The Journal of cell biology · 2004Article
- Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle.Biophysical journal · 2002Article
- Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.Biophysical journal · 2002Article
- Type 1 and type 3 ryanodine receptors generate different Ca(2+) release event activity in both intact and permeabilized myotubes.Biophysical journal · 2001Article
- Mutations to Gly2370, Gly2373 or Gly2375 in malignant hyperthermia domain 2 decrease caffeine and cresol sensitivity of the rabbit skeletal-muscle Ca2+-release channel (ryanodine receptor isoform 1).The Biochemical journal · 2001Article
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Authors and funding
7 authors.
Funding
Abstract
The ryanodine receptor (RyR)/Ca2+ release channel is an essential component of excitation-contraction coupling in striated muscle cells. To study the function and regulation of the Ca2+ release channel, we tested the effect of caffeine on the full-length and carboxyl-terminal portion of skeletal muscle RyR expressed in a Chinese hamster ovary (CHO) cell line. Caffeine induced openings of the full length RyR channels in a concentration-dependent manner, but it had no effect on the carboxyl-terminal RyR channels. CHO cells expressing the carboxyl-terminal RyR proteins displayed spontaneous changes of intracellular [Ca2+]. Unlike the native RyR channels in muscle cells, which display localized Ca2+ release events (i.e., "Ca2+ sparks" in cardiac muscle and "local release events" in skeletal muscle), CHO cells expressing the full length RyR proteins did not exhibit detectable spontaneous or caffeine-induced local Ca2+ release events. Our data suggest that the binding site for caffeine is likely to reside within the amino-terminal portion of RyR, and the localized Ca2+ release events observed in muscle cells may involve gating of a group of Ca2+ release channels and/or interaction of RyR with muscle-specific proteins.
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