ArticleThe Journal of experimental medicine1997
A novel antioxidant gene from Mycobacterium tuberculosis.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 106 citations in OpenAlex.
- Article
- The protective effect of a novel antioxidant gene from Mycobacterium avium against nitrosative and oxidative stress in E. coli.World journal of microbiology & biotechnology · 2017Article
- The emerging role of gasotransmitters in the pathogenesis of tuberculosis.Nitric oxide : biology and chemistry · 2016Review
- Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages.Journal of leukocyte biology · 2015Article
- Disruption of immune regulation by microbial pathogens and resulting chronic inflammation.Journal of cellular physiology · 2013Review
- In silico identification of epitopes in Mycobacterium avium subsp. paratuberculosis proteins that were upregulated under stress conditions.Clinical and vaccine immunology : CVI · 2012Article
- Bactericidal effect of S-nitrosothiols against clinical isolates from keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Tuberculosis: new aspects of an old disease.International journal of cell biology · 2011Article
- Cloning and characterization of Rv0621 gene related to surfactant stress tolerance in Mycobacterium tuberculosis.Molecular biology reports · 2009Article
- Resistance to peroxynitrite in Neisseria gonorrhoeae.Microbiology (Reading, England) · 2009Article
- Identification of a copper-binding metallothionein in pathogenic mycobacteria.Nature chemical biology · 2008Article
- Sabine Ehrt: searching for mycobacterial stress points. Interview by Hema Bashyam.The Journal of experimental medicine · 2008Article
- The timing of TNF and IFN-gamma signaling affects macrophage activation strategies during Mycobacterium tuberculosis infection.Journal of theoretical biology · 2008Article
- The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species.BMC microbiology · 2007Article
- A Mycobacterium marinum mel2 mutant is defective for growth in macrophages that produce reactive oxygen and reactive nitrogen species.Infection and immunity · 2007Article
- Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy.Clinical microbiology reviews · 2006Review
- Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.Infection and immunity · 2006Article
- S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis.Infection and immunity · 2003Article
- Virulent Mycobacterium fortuitum restricts NO production by a gamma interferon-activated J774 cell line and phagosome-lysosome fusion.Infection and immunity · 2002Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Among the major antimicrobial products of macrophages are reactive intermediates of the oxidation of nitrogen (RNI) and the reduction of oxygen (ROI). Selection of recombinants in acidified nitrite led to the cloning of a novel gene, noxR1, from a pathogenic clinical isolate of Mycobacterium tuberculosis. Expression of noxR1 conferred upon Escherichia coli and Mycobacterium smegmatis enhanced ability to resist RNI and ROI, whether the bacteria were exposed to exogenous compounds in medium or to endogenous products in macrophages. These studies provide the first identification of an RNI resistance mechanism in mycobacteria, point to a new mechanism for resistance to ROI, and raise the possibility that inhibition of the noxR1 pathway might enhance the ability of macrophages to control tuberculosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.