ArticleAmerican journal of human genetics1997
A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA13, maps to chromosome 6p.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- NovelJournal of pediatric genetics · 2020Article
- Genetic Hearing Loss and Gene Therapy.Genomics & informatics · 2018Article
- From Structure to Phenotype: Impact of Collagen Alterations on Human Health.International journal of molecular sciences · 2018Review
- Audiological findings in otospondylomegaepiphyseal dysplasia (OSMED) associated with a novel mutation in COL11A2.International journal of pediatric otorhinolaryngology · 2011Article
- Mutations in TMC1 are a common cause of DFNB7/11 hearing loss in the Iranian population.The Annals of otology, rhinology, and laryngology · 2010Article
- Tectorial membrane material properties in Tecta(Y)(1870C/+) heterozygous mice.Biophysical journal · 2010Article
- Col11a2 deletion reveals the molecular basis for tectorial membrane mechanical anisotropy.Biophysical journal · 2009Article
- A gene for fluctuating, progressive autosomal dominant nonsyndromic hearing loss, DFNA16, maps to chromosome 2q23-24.3.American journal of human genetics · 1999Article
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7 authors.
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Abstract
Nonsyndromic hearing loss (NSHL) is the most common type of hearing impairment in the elderly. Environmental and hereditary factors play an etiologic role, although the relative contribution of each is unknown. To date, 39 NSHL genes have been localized. Twelve produce autosomal dominant hearing loss, most frequently postlingual in onset and progressive in nature. We have ascertained a large, multigenerational family in which a gene for autosomal dominant NSHL is segregating. Affected individuals experience progressive hearing loss beginning in the 2d-4th decades, eventually making the use of amplification mandatory. A novel locus, DFNA13, was identified on chromosome 6p; the disease gene maps to a 4-cM interval flanked by D6S1663 and D6S1691, with a maximum two-point LOD score of 6.409 at D6S299.
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