ArticleAmerican journal of human genetics1997
Genome scanning for segments shared identical by descent among distant relatives in isolated populations.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Article
- A regression-based association test for case-control studies that uses inferred ancestral haplotype similarity.Annals of human genetics · 2009Article
- Article
- A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands.Molecular psychiatry · 2006Article
- Evidence for a novel glaucoma locus at chromosome 3p21-22.Human genetics · 2005Article
- Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands.Molecular psychiatry · 2004Article
- Prospects for whole genome linkage disequilibrium mapping in domestic dog breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit.American journal of human genetics · 2003Article
- Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene.American journal of human genetics · 2003Article
- Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18.American journal of human genetics · 1999Article
- Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations.American journal of human genetics · 1999Article
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Abstract
In this paper, we address some of the statistical issues concerning false-positive rates that arise when the whole genome, or a portion thereof, is scanned in distantly related individuals, to search for a disease locus. We derive a method for correcting false-positive probabilities for the large number of comparisons that are performed when scanning a large portion of the genome. We consider both the idealized situation of a dense set of fully informative markers and the more realistic data-collection strategy of an initial scan at low resolution to identify promising areas, which then are typed with markers at high resolution. We also examine the accuracy of false-positive rates approximated using a conservative estimate of the separation distance between affected individuals in the current generation and the common ancestral couple. Calculation of false-positive rates when inbreeding is present in the pedigree also is considered.
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