ArticleProceedings of the National Academy of Sciences of the United States of America1997
The selectivity of the hair cell's mechanoelectrical-transduction channel promotes Ca2+ flux at low Ca2+ concentrations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 82 citations in OpenAlex.
- Contribution of TRPC3-mediated CaPflugers Archiv : European journal of physiology · 2023Article
- Mitochondrial calcium uniporter is essential for hearing and hair cell preservation in congenic FVB/NJ mice.Scientific reports · 2021Article
- TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.Neuron · 2018Article
- Mechanically Gated Ion Channels in Mammalian Hair Cells.Frontiers in cellular neuroscience · 2018Review
- Simulating the Chan-Hudspeth experiment on an active excised cochlear segment.The Journal of the Acoustical Society of America · 2017Article
- Article
- The how and why of identifying the hair cell mechano-electrical transduction channel.Pflugers Archiv : European journal of physiology · 2015Review
- The physiology of mechanoelectrical transduction channels in hearing.Physiological reviews · 2014Review
- Dissection of gain control mechanisms in Drosophila mechanotransduction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structure.Journal of neurophysiology · 2012Article
- Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction.Nature communications · 2011Review
- Regulation of sodium transport in the inner ear.Hearing research · 2011Review
- Asymmetric distribution of cadherin 23 and protocadherin 15 in the kinocilial links of avian sensory hair cells.The Journal of comparative neurology · 2010Article
- Localisation of the mechanotransducer channels in mammalian cochlear hair cells provides clues to their gating.The Journal of physiology · 2010Review
- Aminoglycoside-induced phosphatidylserine externalization in sensory hair cells is regionally restricted, rapid, and reversible.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Article
- A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- FM1-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli.Molecular pain · 2007Article
- The micromachinery of mechanotransduction in hair cells.Annual review of neuroscience · 2007Review
- Steady-state adaptation of mechanotransduction modulates the resting potential of auditory hair cells, providing an assay for endolymph [Ca2+].The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mechanoelectrical-transduction channel of the hair cell is permeable to both monovalent and divalent cations. Because Ca2+ entering through the transduction channel serves as a feedback signal in the adaptation process that sets the channel's open probability, an understanding of adaptation requires estimation of the magnitude of Ca2+ influx. To determine the Ca2+ current through the transduction channel, we measured extracellular receptor currents with transepithelial voltage-clamp recordings while the apical surface of a saccular macula was bathed with solutions containing various concentrations of K+, Na+, or Ca2+. For modest concentrations of a single permeant cation, Ca2+ carried much more receptor current than did either K+ or Na+. For higher cation concentrations, however, the flux of Na+ or K+ through the transduction channel exceeded that of Ca2+. For mixtures of Ca2+ and monovalent cations, the receptor current displayed an anomalous mole-fraction effect, which indicates that ions interact while traversing the channel's pore. These results demonstrate not only that the hair cell's transduction channel is selective for Ca2+ over monovalent cations but also that Ca2+ carries substantial current even at low Ca2+ concentrations. At physiological cation concentrations, Ca2+ flux through transduction channels can change the local Ca2+ concentration in stereocilia in a range relevant for the control of adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.