ArticleProceedings of the National Academy of Sciences of the United States of America1997
Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 154 citations in OpenAlex.
- Regulatory T cells in stroke inflammation: Therapeutic perspectives.Neural regeneration research · 2026Article
- Targeting T cell metabolism and polarization to modulate post-stroke immune responses and improve outcomes.Frontiers in immunology · 2026Article
- T Cell Response in Ischemic Stroke: From Mechanisms to Translational Insights.Frontiers in immunology · 2021Review
- Endothelial Cell-Specific Transcriptome Reveals Signature of Chronic Stress Related to Worse Outcome After Mild Transient Brain Ischemia in Mice.Molecular neurobiology · 2020Article
- Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?Frontiers in aging neuroscience · 2020Review
- Adaptive Immunity Regulation and Cerebral Ischemia.Frontiers in immunology · 2020Review
- The impact of sex and age on T cell immunity and ischemic stroke outcomes.Cellular immunology · 2019Review
- Autoimmunity After Ischemic Stroke and Brain Injury.Frontiers in immunology · 2019Review
- Immune Tolerance Therapy: A New Method for Treatment of Traumatic Brain Injury.Chinese medical journal · 2018Review
- Long-term T cell responses in the brain after an ischemic stroke.Discovery medicine · 2017Review
- Microglial Interferon Signaling and White Matter.Neurochemical research · 2017Review
- The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises.American journal of hematology · 2017Review
- mTOR regulates neuroprotective effect of immunized CD4+Foxp3+ T cells in optic nerve ischemia.Scientific reports · 2016Article
- Antigen Presentation After Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Blocking Sympathetic Nervous System Reverses Partially Stroke-Induced Immunosuppression but does not Aggravate Functional Outcome After Experimental Stroke in Rats.Neurochemical research · 2016Article
- Could Intrathymic Injection of Myelin Basic Protein Suppress Inflammatory Response After Co-culture of T Lymphocytes and BV-2 Microglia Cells?Chinese medical journal · 2016Article
- Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Stroke induces a rapid adaptive autoimmune response to novel neuronal antigens.Discovery medicine · 2015Article
- Molecular and cellular immune responses to ischemic brain injury.Translational stroke research · 2014Review
- The Immune Response to Acute Focal Cerebral Ischemia and Associated Post-stroke Immunodepression: A Focused Review.Aging and disease · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune mechanisms contribute to cerebral ischemic injury. Therapeutic immunosuppressive options are limited due to systemic side effects. We attempted to achieve immunosuppression in the brain through oral tolerance to myelin basic protein (MBP). Lewis rats were fed low-dose bovine MBP or ovalbumin (1 mg, five times) before 3 h of middle cerebral artery occlusion (MCAO). A third group of animals was sensitized to MBP but did not survive the post-stroke period. Infarct size at 24 and 96 h after ischemia was significantly less in tolerized animals. Tolerance to MBP was confirmed in vivo by a decrease in delayed-type hypersensitivity to MBP. Systemic immune responses, characterized in vitro by spleen cell proliferation to Con A, lipopolysaccharide, and MBP, again confirmed antigen-specific immunologic tolerance. Immunohistochemistry revealed transforming growth factor beta1 production by T cells in the brains of tolerized but not control animals. Systemic transforming growth factor beta1 levels were equivalent in both groups. Corticosterone levels 24 h after surgery were elevated in all sham-operated animals and ischemic control animals but not in ischemic tolerized animals. These results demonstrate that antigen-specific modulation of the immune response decreases infarct size after focal cerebral ischemia and that sensitization to the same antigen may actually worsen outcome.
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