ArticleProceedings of the National Academy of Sciences of the United States of America1997
Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- A global search for novel transcription factors impacting the Neurospora crassa circadian clock.G3 (Bethesda, Md.) · 2021Article
- Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension.Frontiers in cell and developmental biology · 2021Article
- The C3HC type zinc-finger protein (ZFC3) interacting with Lon/MAP1 is important for mitochondrial gene regulation, infection hypha development and longevity of Magnaporthe oryzae.BMC microbiology · 2020Article
- Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging.Microbial cell (Graz, Austria) · 2018Article
- Overexpression of Pa_1_10620 encoding a mitochondrial Podospora anserina protein with homology to superoxide dismutases and ribosomal proteins leads to lifespan extension.Current genetics · 2015Article
- Identification of autophagy as a longevity-assurance mechanism in the aging model Podospora anserina.Autophagy · 2014Article
- Poly(ADP-ribose) polymerase is a substrate recognized by two metacaspases of Podospora anserina.Eukaryotic cell · 2013Article
- Whole-Genome Sequencing of Sordaria macrospora Mutants Identifies Developmental Genes.G3 (Bethesda, Md.) · 2012Article
- Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems.Oxidative medicine and cellular longevity · 2012Review
- Article
- Article
- DNA damage and base excision repair in mitochondria and their role in aging.Journal of aging research · 2010Article
- Mitochondrial DNA repair and association with aging--an update.Experimental gerontology · 2010Review
- A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing.Mechanisms of ageing and development · 2009Article
- Increasing organismal healthspan by enhancing mitochondrial protein quality control.Nature cell biology · 2009Article
- Podospora anserina: a model organism to study mechanisms of healthy ageing.Molecular genetics and genomics : MGG · 2008Review
- Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina metabolism and life span.Eukaryotic cell · 2004Article
- Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina.Molecular and cellular biology · 2001Article
- A causal link between respiration and senescence in Podospora anserina.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina.Molecular and cellular biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Podospora anserina is a filamentous fungus with a limited life span. Life span is controlled by nuclear and extranuclear genetic traits. Herein we report the nature of four alterations in the nuclear gene grisea that lead to an altered morphology, a defect in the formation of female gametangia, and an increased life span. Three sequence changes are located in the 5' upstream region of the grisea ORF. One mutation is a G --> A transition at the 5' splice site of the single intron of the gene, leading to a RNA splicing defect. This loss-of-function affects the amplification of the first intron of the mitochondrial cytochrome c oxidase subunit I gene (COI) and the specific mitochondrial DNA rearrangements that occur during senescence of wild-type strains. Our results indicate that the nuclear gene grisea is part of a molecular machinery involved in the control of mitochondrial DNA reorganizations. These DNA instabilities accelerate but are not a prerequisite for the aging of P. anserina cultures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.