Evidence map›Paper›PMID 9380703›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1997

Xenopus Cdc6 confers sperm binding competence to oocytes without inducing their maturation.

J Tian, G H Thomsen, H Gong, W J Lennarz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

J TianDepartment of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794-5215, USA.
G H Thomsen
H Gong
W J Lennarz
State University of New York · USStony Brook University · US

Funding

PLASMA MEMBRANE CHANGES IN FERTILIZATIONR01HD018590 · NICHD · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI LENNARZ, WILLIAM J · 1985 to 2001
$475k
NICHD NIH HHS HD18590
6 · The paper itself

Abstract

Amphibian eggs normally require meiotic maturation to be competent for fertilization. A necessary prerequisite for this event is sperm binding, and we show that under normal physiological conditions this property is acquired at, but not before, meiotic maturation. Immature oocytes do not bind sperm, but injection of total egg poly(A)+ mRNA into immature oocytes confers sperm binding in the absence of meiotic maturation. Using an expression cloning approach we have isolated a single cDNA from egg poly(A)+ mRNA that can induce sperm binding in immature oocytes. The cDNA was found to encode Xenopus Cdc6, a protein that previously has been shown to function in initiation of DNA replication and cell cycle control. This unanticipated finding provides evidence of a link between a regulator of the cell cycle and alterations in cell surface properties that affect gamete binding.

Indexed as

Saccharomyces cerevisiae ProteinsSperm-Ovum InteractionsAmino Acid SequenceAnimalsBase SequenceCell Cycle ProteinsCloning, MolecularDNA, ComplementaryFemaleMaleMeiosisMolecular Sequence DataOocytesOviductsProgesteroneRNA, MessengerCDC6 protein, S cerevisiaeCell Cycle ProteinsDNA, ComplementaryProgesteroneRNA, MessengerSaccharomyces cerevisiae Proteins

Identifiers

PMID9380703
PMCPMC23465
OpenAlexW2082716983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.