ReviewNucleic acids research1997
The mechanism of U insertion/deletion RNA editing in kinetoplastid mitochondria.
Review in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- A genome-wide genetic screen identifies a novel kDNA replication protein in trypanosomes.Nucleic acids research · 2026Article
- RNA Editing in Cancer Progression.Cancers · 2023Review
- Structural basis for guide RNA selection by the RESC1-RESC2 complex.Nucleic acids research · 2023Article
- Article
- A-to-I RNA editing in bacteria increases pathogenicity and tolerance to oxidative stress.PLoS pathogens · 2020Article
- Gene fragmentation and RNA editing without borders: eccentric mitochondrial genomes of diplonemids.Nucleic acids research · 2020Article
- Article
- Article
- Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen.Parasites & vectors · 2015Article
- A common tRNA modification at an unusual location: the discovery of wyosine biosynthesis in mitochondria.Nucleic acids research · 2015Article
- Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria.Nucleic acids research · 2014Article
- Article
- The importance of the 45 S ribosomal small subunit-related complex for mitochondrial translation in Trypanosoma brucei.The Journal of biological chemistry · 2013Article
- Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei.RNA (New York, N.Y.) · 2012Article
- Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion.RNA (New York, N.Y.) · 2008Article
- A bifunctional tRNA import receptor from Leishmania mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- T. brucei RNA editing: action of the U-insertional TUTase within a U-deletion cycle.RNA (New York, N.Y.) · 2006Article
- Discovery of new genes and deletion editing in Physarum mitochondria enabled by a novel algorithm for finding edited mRNAs.Nucleic acids research · 2005Article
- The 3'-untranslated region of cytochrome oxidase II mRNA functions in RNA editing of African trypanosomes exclusively as a cis guide RNA.RNA (New York, N.Y.) · 2005Article
- Comparative analysis of editosome proteins in trypanosomatids.Nucleic acids research · 2003Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in in vitrosystems and identification of putative enzymatic activities have led to the acceptance of a modified 'enzyme cascade' model for U insertion/deletion RNA editing in kinetoplastid mitochondria. Models involving the transfer of uridines (Us) from the 3'-end of gRNA to the editing site appear to be untenable. Two types of in vitrosystems have been reported: (i) a gRNA-independent U insertion activity that is dependent on the secondary structure of the mRNA; (ii) a gRNA-dependent U insertion activity that requires addition of a gRNA that can form an anchor duplex with the pre-edited mRNA and which contains guiding A and G nucleotides to base pair with the added Us. In the case of the gRNA-mediated reaction, the precise site of cleavage is at the end of the gRNA-mRNA anchor duplex, as predicted by the original model. The model has been modified to include the addition of multiple Us to the 3'-end of the 5'-cleavage fragment, followed by the formation of base pairs with the guiding nucleotides and trimming back of the single-stranded oligo(U) 3'-overhang. The two fragments, which are held together by the gRNA 'splint', are then ligated. Circumstantial in vitroevidence for involvement of an RNA ligase and an endoribonuclease, which are components of a 20S complex, was obtained. Efforts are underway in several laboratories to isolate and characterize specific components of the editing machinery.
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