ArticleThe Journal of physiology1997
Angiotensin II inhibition of ATP-sensitive K+ currents in rat arterial smooth muscle cells through protein kinase C.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 82 citations in OpenAlex.
- Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels.Frontiers in physiology · 2022Article
- Sexual dimorphism in vascular ATP-sensitive KThe Journal of physiology · 2021Article
- Article
- Angiotensin II Receptor-Neprilysin Inhibitor Sacubitril/Valsartan Improves Endothelial Dysfunction in Spontaneously Hypertensive Rats.Journal of the American Heart Association · 2017Article
- Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system.British journal of pharmacology · 2014Review
- K(ATP) channel action in vascular tone regulation: from genetics to diseases.Sheng li xue bao : [Acta physiologica Sinica] · 2012Review
- Muscle KATP channels: recent insights to energy sensing and myoprotection.Physiological reviews · 2010Review
- Localization of ATP-sensitive K+ channel subunits in rat submandibular gland.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway, and chromosome 13-substituted consomic rat strains: role of large conductance Ca2+ and voltage-activated potassium channels.The Journal of pharmacology and experimental therapeutics · 2009Article
- A short motif in Kir6.1 consisting of four phosphorylation repeats underlies the vascular KATP channel inhibition by protein kinase C.The Journal of biological chemistry · 2008Article
- Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells.The Journal of physiology · 2006Article
- Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.The Journal of physiology · 2002Article
- Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K(ATP) channels by protein kinase A.The Journal of physiology · 2001Article
- Angiotensin II inhibits rat arterial KATP channels by inhibiting steady-state protein kinase A activity and activating protein kinase Ce.The Journal of physiology · 2001Article
- ATP-sensitive potassium channels in capillaries isolated from guinea-pig heart.The Journal of physiology · 2000Article
- Functional and electrophysiological effects of a novel imidazoline-based K(ATP) channel blocker, IMID-4F.British journal of pharmacology · 1999Article
- Inhibition of vascular K(ATP) channels by U-37883A: a comparison with cardiac and skeletal muscle.British journal of pharmacology · 1999Article
- Basal activation of ATP-sensitive potassium channels in murine colonic smooth muscle cell.Biophysical journal · 1998Article
- Role of tyrosine phosphorylation in leptin activation of ATP-sensitive K+ channels in the rat insulinoma cell line CRI-G1.The Journal of physiology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of the vasoconstrictor angiotensin II (Ang II) on whole-cell ATP-sensitive K+ currents (IK,ATP) of smooth muscle cells isolated enzymatically from rat mesenteric arteries were investigated using the patch clamp technique. 2. Ang II, at a physiological concentration (100 nM), reduced IK,ATP activated by 0.1 mM internal ATP and 10 microM levcromakalim by 36.4 +/- 2.3%. 3. The protein kinase C (PKC) activator 1-oleoyl-2-acetyl-sn-glycerol (OAG, 1 microM) reduced IK,ATP by 44.1 +/- 2.7%. GDP beta S (1 mM), included in the pipette solution, abolished the inhibition by Ang II, while that by OAG was unaffected. 4. Pretreatment with the PKC inhibitors staurosporine (100 nM) or calphostin C (500 nM) prevented the Ang II-induced inhibition of IK,ATP. 5. Ang II inhibition was unaffected by cell dialysis with PKA inhibitor peptide (5 microM), and the PKA inhibitor Rp-cAMPS (100 microM) did not reduce IK,ATP. 6. Our results suggest that Ang II modulates KATP channels through activation of PKC but not through inhibition of PKA.
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