ArticleJournal of clinical pathology1997
A panel of antibodies for the immunostaining of Bouin's fixed bone marrow trephine biopsies.
Article in Journal of clinical pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Imatinib‑induced gynecomastia: A case report.Experimental and therapeutic medicine · 2024Article
- Picrosirius Red Staining: Revisiting Its Application to the Qualitative and Quantitative Assessment of Collagen Type I and Type III in Tendon.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Article
- Optimal processing of bone marrow trephine biopsy: the Hammersmith Protocol.Journal of clinical pathology · 2006Review
- How we process trephine biopsy specimens: epoxy resin embedded bone marrow biopsies.Journal of clinical pathology · 2005Article
- Immunohistochemical assays in prostatic biopsies processed in Bouin's fixative.Journal of clinical pathology · 2005Article
- L26 (CD20) staining of Bouin fixed bone marrow biopsies.Journal of clinical pathology · 1999Article
- Bouin's fixed trephine biopsies.Journal of clinical pathology · 1999Article
- Antibody panel in diagnosis of lymphoid neoplasms.Journal of clinical pathology · 1998Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess a panel of antibodies on Bouin's fixed bone marrow trephine (BMT) biopsies. These biopsies are widely used in routine diagnosis of various haematological malignancies and may be the sole material available in many centres; however, information regarding the immunostaining of this material is lacking.
methodsBiopsies were taken from 72 patients presenting with various haematological malignancies (leukaemia, 38; lymphoma, 14; multiple myeloma, 20). A panel of antibodies was assessed on Bouin's fixed BMT biopsies by the alkaline phosphatase-antialkaline phosphatase method.
resultsThree B (MB2, LN-2, Ki-B5) and two T cell lineage antibodies (UCHL-1, CD3-r) reliably identified lymphoid cells, while MPO-r, Leu-M1/CD15, and KP-1/CD68 recognised cells from the myeloid or histiocytic/macrophage series. Reed-Sternberg cells were stained by LN-2, Leu-M1, and CD30. Antibodies specific for plasma cells (VS38) and hairy cells (DBA.44) gave a variable pattern of staining. Among the proliferation markers, proliferative cell nuclear antigen but not Ki-67 related antibodies were effective.
conclusionThis study presents a panel of antibodies with reactivity not restricted to common fixatives that are also suitable for Bouin's fixed BMT biopsies.
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