ArticleImmunology1997
Human monocyte-derived macrophages and dendritic cells are comparably effective in vitro in presenting HLA class I-restricted exogenous peptides.
Article in Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Injection by various routes of melanoma antigen-associated macrophages: biodistribution and clinical effects.Cancer immunology, immunotherapy : CII · 2003Trial
- Article
- Fetal exposure to oncoantigen elicited antigen-specific adaptive immunity against tumorigenesis.Journal for immunotherapy of cancer · 2020Article
- Article
- Expression and clinical significance of cyclooxygenase-2 and microRNA-143 in osteosarcoma.Experimental and therapeutic medicine · 2015Article
- Myeloma-specific multiple peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma and other plasma cell disorders.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Methamphetamine modulates DC-SIGN expression by mature dendritic cells.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2006Article
- Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells: implications for HIV-1 pathogenesis.Molecular diagnosis & therapy · 2006Article
- Effect of bone marrow-derived monocytes transfected with RNA of mouse colon carcinoma on specific antitumor immunity.World journal of gastroenterology · 2005Article
- Effect of the preventive-therapeutic administration of melatonin on mammary tumour-bearing animals.Molecular and cellular biochemistry · 2005Article
- Rapid induction of cytotoxic T-cell response against cervical cancer cells by human papillomavirus type 16 E6 antigen gene delivery into human dendritic cells by an adeno-associated virus vector.Cancer gene therapy · 2001Article
- Differentiation of antigen-presenting cells (dendritic cells and macrophages) for therapeutic application in patients with lymphoma.Leukemia · 2000Article
- Polyomavirus-infected dendritic cells induce antiviral CD8(+) T lymphocytes.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent experimental data have shown that mice could be immunized efficiently, in particular against cancer, by the injection of antigen-loaded dendritic cells (DC) or macrophages (MPH). In the present work, these two antigen-presenting cells (APC) were prepared in humans from circulating mononuclear cells (MNC). MPH were obtained from MNC that were cultured in hydrophobic plastic bags and purified by elutriation. DC were from the culture of adherent elutriation-purified monocytes in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). The two APC were prepared in parallel from the same donors and their phenotype and antigen-presenting capacity were compared. DC differed from MPH by a higher expression of HLA-DR and CD23 and a lower expression of CD14, CD64 and of adhesion molecules. DC and MPH were comparably effective in (a) enhancing the mitotic response of autologous lymphocytes to immobilized anti-CD3 (accessory function); (b) presenting melanoma peptides to specific cytotoxic T lymphocyte (CTL) clones; and (c) stimulating the generation of CTL directed against a myxovirus influenza peptide. However, DC were more effective than MPH in inducing the mitotic response of allogeneic peripheral blood leucocytes (PBL), possibly because of their higher expression of HLA class II molecules. In conclusion, DC and MPH prepared from blood MNC did not differ substantially in their ability to activate HLA class I-restricted T-cell responses by exogenous peptide presentation.
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