ArticleGut1997
Rectal cell proliferation and colon cancer risk in patients with hypergastrinaemia.
Article in Gut, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Influence of proton pump inhibitor use in gastrointestinal polyps.The Kaohsiung journal of medical sciences · 2010Trial
- Gastric autoimmune disorders in patients with chronic hepatitis C before, during and after interferon-alpha therapy.World journal of gastroenterology · 2003Trial
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.International journal of molecular sciences · 2019Review
- Article
- Article
- Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee-Indiana Adenoma Recurrence Study.Molecular carcinogenesis · 2017Article
- Helicobacter pylori and colorectal neoplasia: Is there a causal link?World journal of gastroenterology · 2016Review
- Combination of Triple Therapy and Chronic PPI Use May Decrease Risk of Colonic Adenomatous Polyps in Helicobacter pylori Infection.Gastroenterology research and practice · 2015Article
- The association of H. pylori and colorectal adenoma: does it exist in the US Hispanic population?Journal of gastrointestinal oncology · 2014Article
- Association of helicobacter pylori infection and colon cancer.Journal of clinical medicine research · 2012Article
- Adverse effects of long-term proton pump inhibitor therapy.Digestive diseases and sciences · 2011Review
- CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells.International journal of cancer · 2010Article
- Colorectal cancer risk in relation to use of acid suppressive medications.Pharmacoepidemiology and drug safety · 2009Article
- Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women.Journal of gastroenterology · 2005Article
- Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and epithelial growth factor receptor expression and has no effect on apoptosis and p53 expression.World journal of gastroenterology · 2005Article
- Detection of anti-HAV antibody with dot immunogold filtration assay.World journal of gastroenterology · 2003Article
- Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence.British journal of cancer · 2002Article
- Differences in plasma gastrin, CEA, and CA 19-9 concentration in patients with proximal and distal colorectal cancer.International journal of gastrointestinal cancer · 2002Article
- Article
- Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence.Gut · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe influence of gastrin on the colonic mucosa is still uncertain. Some authors have suggested a stimulating effect on the growth of normal and malignant colonic epithelium, while others have shown no association between gastrin and neoplastic development.
aimsTo evaluate the effect of gastrin on colorectal cell proliferation, patients with chronic endogenous hypergastrinaemia underwent proctoscopy. Biopsy specimens were taken in order to study rectal cell kinetics. PATIENTS AND CONTROLS: Ten patients with chronic autoimmune gastritis (CAG), six patients with Zollinger-Ellison syndrome (ZES), and 16 hospital controls took part in this study. Patients with CAG and ZES had basal serum gastrin concentrations significantly higher than controls (p < 0.001).
methodsImmunohistochemistry was performed on 3 microns sections of rectal biopsy specimens incubated with 5'-bromodeoxyuridine.
resultsThe percentage of proliferating cells in the entire crypts (overall labelling index) was similar in all the groups. However, the labelling frequency in the upper two fifths of the glands (phi h value) was significantly higher in patients with CAG or ZES compared with controls (p < 0.01 in both patient groups versus controls).
conclusionsEndogenous hypergastrinaemia is associated with rectal cell proliferation defects, similar to those observed in conditions at high risk for colon cancer. The effect of the increased serum concentrations of gastrin on the colorectal mucosa after treatment with drugs inhibiting gastric acid secretion should be investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.