ArticleMolecular and cellular biology1997
OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- IκBζ is a dual-use coactivator of NF-κB and POU transcription factors.Molecular cell · 2024Article
- CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.Journal of molecular endocrinology · 2023Article
- Drosophila octamer elements and Pdm-1 dictate the coordinated transcription of core histone genes.The Journal of biological chemistry · 2010Article
- Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma.Journal of virology · 2009Article
- B29 gene silencing in pituitary cells is regulated by its 3' enhancer.Journal of molecular biology · 2006Article
- The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Btk expression is controlled by Oct and BOB.1/OBF.1.Nucleic acids research · 2006Article
- Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator.Nucleic acids research · 2004Article
- OBF1 enhances transcriptional potential of Oct1.The EMBO journal · 2003Article
- Activator recruitment by the general transcription machinery: X-ray structural analysis of the Oct-1 POU domain/human U1 octamer/SNAP190 peptide ternary complex.Genes & development · 2002Article
- Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1.Nucleic acids research · 2002Article
- The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.The EMBO journal · 2001Article
- Protein interaction surface of the POU transcription factor UNC-86 selectively used in touch neurons.The EMBO journal · 2000Article
- Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation.Molecular and cellular biology · 2000Article
- Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability.The Biochemical journal · 2000Article
- Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.Genes & development · 1999Article
- Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism.The Biochemical journal · 1999Article
- B-Cell coactivator OBF-1 exhibits unusual transcriptional properties and functions in a DNA-bound Oct-1-dependent fashion.Molecular and cellular biology · 1999Article
- Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity.Molecular and cellular biology · 1999Article
- Selected elements of herpes simplex virus accessory factor HCF are highly conserved in Caenorhabditis elegans.Molecular and cellular biology · 1999Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
OCA-B is a B-cell-specific coregulator of the broadly expressed POU domain transcription factor Oct-1. OCA-B associates with the Oct-1 POU domain, a bipartite DNA-binding structure containing a POU-specific (POU[S]) domain joined by a flexible linker to a POU homeodomain (POU[H]). Here, we show that OCA-B alters the activity of Oct-1 in two ways. It provides a transcriptional activation domain which, unlike Oct-1, activates an mRNA-type promoter effectively, and it stabilizes Oct-1 on the Oct-1-responsive octamer sequence ATGCAAAT. These properties of OCA-B parallel those displayed by the herpes simplex virus Oct-1 coregulator VP16. OCA-B, however, interacts with a different surface of the DNA-bound Oct-1 POU domain, interacting with both the POU(S) and POU(H) domains and the center of the ATGCAAAT octamer sequence. The OCA-B and VP16 interactions with the Oct-1 POU domain are sufficiently different to permit OCA-B and VP16 to bind the Oct-1 POU domain simultaneously. These results emphasize the structural versatility of the Oct-1 POU domain in its interaction with coregulators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.