ArticleMolecular and cellular biology1997
Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- An intron-based timer for circadian rhythms.bioRxiv : the preprint server for biology · 2025Article
- Novel roles for RNA binding proteins squid, hephaesteus, and Hrb27C in Drosophila oogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research.Developmental biology · 2021Review
- An Interaction Network of RNA-Binding Proteins Involved inMolecular & cellular proteomics : MCP · 2020Article
- Transcriptome protection by the expanded family of hnRNPs.RNA biology · 2019Review
- Hrp48 and eIF3d contribute to msl-2 mRNA translational repression.Nucleic acids research · 2018Article
- Article
- Regulation of Notch Signaling by the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex inGenetics · 2017Article
- TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins.Cell · 2016Article
- Biochemical identification of new proteins involved in splicing repression at the Drosophila P-element exonic splicing silencer.Genes & development · 2015Article
- P Transposable Elements in Drosophila and other Eukaryotic Organisms.Microbiology spectrum · 2015Review
- Article
- Molecular determinants of the axonal mRNA transcriptome.Developmental neurobiology · 2014Review
- The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase.PloS one · 2013Article
- Long-term and short-term evolutionary impacts of transposable elements on Drosophila.Genetics · 2012Article
- Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- In vivo colocalisation of oskar mRNA and trans-acting proteins revealed by quantitative imaging of the Drosophila oocyte.PloS one · 2009Article
- Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing.Nucleic acids research · 2009Article
- Genome-wide analysis of alternative pre-mRNA splicing and RNA-binding specificities of the Drosophila hnRNP A/B family members.Molecular cell · 2009Article
- Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The Drosophila melanogaster hnRNP protein, hrp48, is an abundant heterogeneous nuclear RNA-associated protein. Previous biochemical studies have implicated hrp48 as a component of a ribonucleoprotein complex involved in the regulation of the tissue-specific alternative splicing of the P-element third intron (IVS3). We have taken a genetic approach to analyzing the role of hrp48. Mutations in the hrp48 gene were identified and characterized. hrp48 is an essential gene. Hypomorphic mutations which reduce the level of hrp48 protein display developmental defects, including reduced numbers of ommatidia in the eye and morphological bristle abnormalities. Using a P-element third-intron reporter transgene, we found that reduced levels of hrp48 partially relieve IVS3 splicing inhibition in somatic cells. This is the first direct evidence that hrp48 plays a functional role in IVS3 splicing inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.