ArticleMolecular and cellular biology1997
Subunit composition determines E2F DNA-binding site specificity.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 132 citations in OpenAlex.
- E2F1-3 activate Merkel cell polyomavirus early transcription and replication.bioRxiv : the preprint server for biology · 2025Article
- LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression.Cell reports · 2025Article
- Article
- The Breast Cancer Protooncogenes HER2, BRCA1 and BRCA2 and Their Regulation by the iNOS/NOS2 Axis.Antioxidants (Basel, Switzerland) · 2022Review
- Differential regulation of mammalian and avian ATOH1 by E2F1 and its implication for hair cell regeneration in the inner ear.Scientific reports · 2021Article
- AMolecular and cellular biology · 2020Article
- CDK2 regulates the NRF1/The Journal of cell biology · 2019Article
- Activation of E2F-dependent transcription by the mouse cytomegalovirus M117 protein affects the viral host range.PLoS pathogens · 2018Article
- HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy.EMBO molecular medicine · 2017Article
- Novel functions for the transcription factor E2F4 in development and disease.Cell cycle (Georgetown, Tex.) · 2016Review
- E2F1-mediated human POMC expression in ectopic Cushing's syndrome.Endocrine-related cancer · 2016Article
- Structural insights into the DNA-binding specificity of E2F family transcription factors.Nature communications · 2015Article
- CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes.Nucleic acids research · 2013Article
- The DREAM complex: master coordinator of cell cycle-dependent gene expression.Nature reviews. Cancer · 2013Review
- Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting.Genome research · 2013Article
- The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion.PloS one · 2013Article
- Article
- RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.Molecular and cellular biology · 2012Article
- E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.Nucleic acids research · 2012Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The product of the retinoblastoma (Rb) susceptibility gene, Rb-1, regulates the activity of a wide variety of transcription factors, such as E2F, in a cell cycle-dependent fashion. E2F is a heterodimeric transcription factor composed of two subunits each encoded by one of two related gene families, denoted E2F and DP. Five E2F genes, E2F-1 through E2F-5, and two DP genes, DP-1 and DP-2, have been isolated from mammals, and heterodimeric complexes of these proteins are expressed in most, if not all, vertebrate cells. It is not yet clear whether E2F/DP complexes regulate overlapping and/or specific cellular genes. Moreover, little is known about whether Rb regulates all or a subset of E2F-dependent genes. Using recombinant E2F, DP, and Rb proteins prepared in baculovirus-infected cells and a repetitive immunoprecipitation-PCR procedure (CASTing), we have identified consensus DNA-binding sites for E2F-1/DP-1, E2F-1/DP-2, E2F-4/DP-1, and E2F-4/DP-2 complexes as well as an Rb/E2F-1/DP-1 trimeric complex. Our data indicate that (i) E2F, DP, and Rb proteins each influence the selection of E2F-binding sites; (ii) E2F sites differ with respect to their intrinsic DNA-bending properties; (iii) E2F/DP complexes induce distinct degrees of DNA bending; and (iv) complex-specific E2F sites selected in vitro function distinctly as regulators of cell cycle-dependent transcription in vivo. These data indicate that the specific sequence of an E2F site may determine its role in transcriptional regulation and suggest that Rb/E2F complexes may regulate subsets of E2F-dependent cellular genes.
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