ArticleMolecular and cellular biology1997
Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- TRα2-An Untuned Second Fiddle or Fine-Tuning Thyroid Hormone Action?International journal of molecular sciences · 2022Review
- Molecular mechanisms of transcriptional control by Rev-erbα: An energetic foundation for reconciling structure and binding with biological function.Protein science : a publication of the Protein Society · 2015Article
- TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo.PloS one · 2014Article
- LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.Molecular and cellular biology · 2011Article
- Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.Molecular and cellular biology · 2008Article
- Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3.FEBS letters · 2007Article
- Transgenic analysis reveals that thyroid hormone receptor is sufficient to mediate the thyroid hormone signal in frog metamorphosis.Molecular and cellular biology · 2004Article
- A permissive retinoid X receptor/thyroid hormone receptor heterodimer allows stimulation of prolactin gene transcription by thyroid hormone and 9-cis-retinoic acid.Molecular and cellular biology · 2004Article
- A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.The EMBO journal · 2003Article
- Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer.Molecular and cellular biology · 2002Article
- Oligomerization of ETO is obligatory for corepressor interaction.Molecular and cellular biology · 2001Article
- Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.Genes & development · 2000Article
- Transcriptional anti-repression. Thyroid hormone receptor beta-2 recruits SMRT corepressor but interferes with subsequent assembly of a functional corepressor complex.The Journal of biological chemistry · 1999Article
- A novel role for helix 12 of retinoid X receptor in regulating repression.Molecular and cellular biology · 1999Article
- Glucose and thyroid hormone co-regulate the expression of the intestinal fructose transporter GLUT5.The Biochemical journal · 1999Article
- Retinoid isomers differ in the ability to induce release of SMRT corepressor from retinoic acid receptor-alpha.The Journal of biological chemistry · 1999Article
- Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.Molecular and cellular biology · 1998Article
- Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Thyroid hormone receptor (TR) functions as part of multiprotein complexes that also include retinoid X receptor (RXR) and transcriptional coregulators. We have found that both the TR CoR box and ninth heptad are required for RXR interaction and in turn for interaction with corepressor proteins N-CoR and SMRT. Remarkably, the recruitment of RXR to repression-defective CoR box and ninth-heptad mutants via a heterologous dimerization interface restores both corepressor interaction and repression. The addition of thyroid hormone obviates the CoR box requirement for RXR interaction, provided that the AF2 activation helix at the C terminus of TR is intact. These results indicate that RXR differentially recognizes the unliganded and liganded conformations of TR and that these differences appear to play a major role in the recruitment of corepressors to TR-RXR heterodimers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.