ArticleMolecular and cellular biology1997
The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 146 citations in OpenAlex.
- Tissue-Specific Tumour Suppressor and Oncogenic Activities of the Polycomb-like Protein MTF2.Genes · 2023Review
- Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.Science advances · 2020Article
- Single vector non-leaky gene expression system for Drosophila melanogaster.Scientific reports · 2017Article
- Chromatin Immunoprecipitation Experiments from WholeBio-protocol · 2017Article
- Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development.Nature genetics · 2016Article
- Adaptive selection and coevolution at the proteins of the Polycomb repressive complexes in Drosophila.Heredity · 2016Article
- A genetic approach to the recruitment of PRC2 at the HoxD locus.PLoS genetics · 2013Article
- Genome-wide polycomb target gene prediction in Drosophila melanogaster.Nucleic acids research · 2012Article
- Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.PloS one · 2012Article
- New partners in regulation of gene expression: the enhancer of Trithorax and Polycomb Corto interacts with methylated ribosomal protein l12 via its chromodomain.PLoS genetics · 2012Article
- Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc.G3 (Bethesda, Md.) · 2011Article
- Polycomb preferentially targets stalled promoters of coding and noncoding transcripts.Genome research · 2011Article
- Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing.Nature structural & molecular biology · 2010Article
- Enhancer-promoter communication at the Drosophila engrailed locus.Development (Cambridge, England) · 2009Article
- Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Unique composition of polycomb repressive complex 1 in hematopoietic stem cells.International journal of hematology · 2007Article
- Chromosomal distribution of PcG proteins during Drosophila development.PLoS biology · 2006Article
- A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities.Genes & development · 2006Article
- Polycomb group-dependent Cyclin A repression in Drosophila.Genes & development · 2006Article
- NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element.Nucleic acids research · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila the Polycomb group genes are required for the long-term maintenance of the repressed state of many developmental regulatory genes. Their gene products are thought to function in a common multimeric complex that associates with Polycomb group response elements (PREs) in target genes and regulates higher-order chromatin structure. We show that the chromodomain of Polycomb is necessary for protein-protein interactions within a Polycomb-Polyhomeotic complex. In addition, Posterior Sex Combs protein coimmunoprecipitates Polycomb and Polyhomeotic, indicating that they are members of a common multimeric protein complex. Immunoprecipitation experiments using in vivo cross-linked chromatin indicate that these three Polycomb group proteins are associated with identical regulatory elements of the selector gene engrailed in tissue culture cells. Polycomb, Polyhomeotic, and Posterior Sex Combs are, however, differentially distributed on regulatory sequences of the engrailed-related gene invected. This suggests that there may be multiple different Polycomb group protein complexes which function at different target sites. Furthermore, Polyhomeotic and Posterior Sex Combs are also associated with expressed genes. Polyhomeotic and Posterior Sex Combs may participate in a more general transcriptional mechanism that causes modulated gene repression, whereas the inclusion of Polycomb protein in the complex at PREs leads to stable silencing.
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