ArticleProceedings of the National Academy of Sciences of the United States of America1997
Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
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Who cites it
133 citing papers in PubMed.
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- Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs.Nature ecology & evolution · 2022Article
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- Pseudomonas aeruginosa Quorum Sensing.Advances in experimental medicine and biology · 2022Article
- Putative RNA Ligase RtcB Affects the Switch between T6SS and T3SS inInternational journal of molecular sciences · 2021Article
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- Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence.Nature communications · 2021Article
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- Zebrafish Embryo Infection Model to InvestigateFrontiers in cellular and infection microbiology · 2021Review
- Pseudomonas aeruginosa cleaves the decoding center of Caenorhabditis elegans ribosomes.PLoS biology · 2020Article
73 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used plants as an in vivo pathogenesis model for the identification of virulence factors of the human opportunistic pathogen Pseudomonas aeruginosa. Nine of nine TnphoA mutant derivatives of P. aeruginosa strain UCBPP-PA14 that were identified in a plant leaf assay for less pathogenic mutants also exhibited significantly reduced pathogenicity in a burned mouse pathogenicity model, suggesting that P. aeruginosa utilizes common strategies to infect both hosts. Seven of these nine mutants contain TnphoA insertions in previously unknown genes. These results demonstrate that an alternative nonvertebrate host of a human bacterial pathogen can be used in an in vivo high throughput screen to identify novel bacterial virulence factors involved in mammalian pathogenesis.
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