ArticleProceedings of the National Academy of Sciences of the United States of America1997
Myc represses transcription of the growth arrest gene gas1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 88 citations in OpenAlex.
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- Haplotype analysis incorporating ancestral origins identified novel genetic loci associated with chicken body weight using an advanced intercross line.Genetics, selection, evolution : GSE · 2024Article
- Transcription factors in microcephaly.Frontiers in neuroscience · 2023Review
- microRNA-mediatedExperimental and therapeutic medicine · 2019Article
- Comparison of EpCAMCancer biology & therapy · 2018Article
- Comparing the gene expression profile of stromal cells from human cord blood and bone marrow: lack of the typical "bone" signature in cord blood cells.Stem cells international · 2013Article
- Molecular marks for epigenetic identification of developmental and cancer stem cells.Clinical epigenetics · 2011Article
- Article
- Myc interacts with Max and Miz1 to repress C/EBPdelta promoter activity and gene expression.Molecular cancer · 2010Article
- Kinetic analysis of the interaction of b/HLH/Z transcription factors Myc, Max, and Mad with cognate DNA.Biochemistry · 2010Article
- Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network.Omics : a journal of integrative biology · 2010Article
- In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue.BMC genomics · 2006Article
- Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1.Oncogene · 2005Article
- Article
- N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.Genes & development · 2002Article
- Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones.Oncogene · 2002Article
- Translocations involving c-myc and c-myc function.Oncogene · 2001Review
- Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Cell proliferation is regulated by the induction of growth promoting genes and the suppression of growth inhibitory genes. Malignant growth can result from the altered balance of expression of these genes in favor of cell proliferation. Induction of the transcription factor, c-Myc, promotes cell proliferation and transformation by activating growth promoting genes, including the ODC and cdc25A genes. We show that c-Myc transcriptionally represses the expression of a growth arrest gene, gas1. A conserved Myc structure, Myc box 2, is required for repression of gas1, and for Myc induction of proliferation and transformation, but not for activation of ODC. Activation of a Myc-estrogen receptor fusion protein by 4-hydroxytamoxifen was sufficient to repress gas1 gene transcription. These findings suggest that transcriptional repression of growth arrest genes, including gas1, is one step in promotion of cell growth by Myc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.