ArticleGenome research1997
Alu insertion polymorphisms and human evolution: evidence for a larger population size in Africa.
Article in Genome research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Structural Variations of Alu Elements in the Kuwaiti Population: Laying the Foundations for Forensic Medicine.Annals of human genetics · 2026Article
- Comparative genomics reveals LINE-1 recombination with diverse RNAs.Cell genomics · 2026Article
- Transposable element-mediated rearrangements are prevalent in human genomes.Nature communications · 2022Article
- AnNAR genomics and bioinformatics · 2022Article
- Translational genomics and beyond in bipolar disorder.Molecular psychiatry · 2021Review
- Short Tandem Repeats as a High-Resolution Marker for Capturing Recent Orangutan Population Evolution.Frontiers in bioinformatics · 2021Article
- Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Alu DNA Polymorphism of Human Tissue Plasminogen Activator (tPA) Gene in Diabetic Jordanian PatientsIranian biomedical journal · 2019Article
- Article
- Novel Bioinformatics Approach Identifies Transcriptional Profiles of Lineage-Specific Transposable Elements at Distinct Loci in the Human Dorsolateral Prefrontal Cortex.Molecular biology and evolution · 2018Article
- A Two-State Model of Tree Evolution and Its Applications to Alu Retrotransposition.Systematic biology · 2018Article
- Genetic Differentiation of North-East Argentina Populations Based on 30 Binary X Chromosome Markers.Frontiers in genetics · 2018Article
- A computational reconstruction ofMobile DNA · 2018Article
- Analysis of lineage-specificMobile DNA · 2018Article
- Recently integratedMobile DNA · 2018Article
- Papio Baboon Species Indicative Alu Elements.Genome biology and evolution · 2017Article
- Genetic differentiation and population structure of five ethnic groups of Punjab (North-West India).Molecular genetics and genomics : MGG · 2016Article
- Polymorphic Alu Insertion/Deletion in Different Caste and Tribal Populations from South India.PloS one · 2016Article
- Transposable element polymorphisms recapitulate human evolution.Mobile DNA · 2015Article
- Genome-wide insights into the genetic history of human populations.Investigative genetics · 2015Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
Alu insertion polymorphisms (polymorphisms consisting of the presence/absence of an Alu element at a particular chromosomal location) offer several advantages over other nuclear DNA polymorphisms for human evolution studies. First, they are typed by rapid, simple, PCR-based assays; second, they are stable polymorphisms-newly inserted Alu elements rarely undergo deletion; third, the presence of an Alu element represents identity by descent-the probability that different Alu elements would independently insert into the exact same chromosomal location is negligible; and fourth, the ancestral state is known with certainty to be the absence of an Alu element. We report here a study of 8 loci in 1500 individuals from 34 worldwide populations. African populations exhibit the most between-population differentiation, and the population tree is rooted in Africa; moreover, the estimated effective time of separation of African versus non-African populations is 137,000 +/- 15,000 years ago, in accordance with other genetic data. However, a principal coordinates analysis indicates that populations from Sahul (Australia and New Guinea) are nearly as close to the hypothetical ancestor as are African populations, suggesting that there was an early expansion of tropical populations of our species. An analysis of heterozygosity versus genetic distance suggests that African populations have had a larger effective population size than non-African populations. Overall, these results support the African origin of modern humans in that an earlier expansion of the ancestors of African populations is indicated.
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