Evidence map›Paper›PMID 9371650›Full record

ArticleJournal of virology1997

Direct interaction between human cytomegalovirus glycoprotein B and cellular annexin II.

R L Pietropaolo, T Compton

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Annexins in Translational Research: Hidden Treasures to Be Found.International journal of molecular sciences · 2018
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R L PietropaoloDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison Medical School, 53706-1532, USA.
T Compton
University of Wisconsin–Madison · US

Funding

Role of Glycoprotein B in HCMV infectionR01AI034998 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KALEJTA, ROBERT F · 1995 to 2010
$2.8M
GLYCOPROTEIN B AND CMV INFECTIONR21AI034998 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI COMPTON, TERESA G · 1999 to 1999
–
NIAID NIH HHS AI-34998
6 · The paper itself

Abstract

Cellular annexin II has been shown to specifically bind human cytomegalovirus (HCMV) and be a component of highly purified virions. In this report, we characterize the interaction of annexin II with HCMV. We found that the binding of annexin II to the HCMV envelope occurs partially through the calcium-dependent phospholipid-binding ability of annexin II since some annexin II was dissociated from virions with chelating agents. However, a substantial proportion of virion-associated annexin II was resistant to chelation, which suggested a calcium-independent interaction between annexin II and an HCMV envelope component. The search for a nonphospholipid component to account for this binding led to the discovery that HCMV glycoprotein B (gpUL55) (gB) can physically interact with annexin II. We present three lines of evidence to support the conclusion that HCMV gB can bind host cell annexin II.

Indexed as

AnimalsAnnexin A2Binding SitesCell LineCell Line, TransformedCytomegalovirusEdetic AcidEgtazic AcidHumansLigandsPrecipitin TestsRabbitsTissue Plasminogen ActivatorViral Envelope ProteinsAnnexin A2Edetic AcidEgtazic Acidglycoprotein B, SimplexvirusLigandsTissue Plasminogen ActivatorViral Envelope Proteins

Identifiers

PMID9371650
PMCPMC230294
OpenAlexW2129251217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.