ArticleJournal of virology1997
Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 79 citations in OpenAlex.
- Novel Compounds Identified by Structure-Based Prion Disease Drug Discovery Using In Silico Screening Delay the Progression of an Illness in Prion-Infected Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice.The Journal of general virology · 2017Article
- Prions: Beyond a Single Protein.Clinical microbiology reviews · 2016Review
- Prion diseases: immunotargets and therapy.ImmunoTargets and therapy · 2016Review
- Review
- Therapies for human prion diseases.American journal of neurodegenerative disease · 2013Review
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.Acta neuropathologica · 2013Article
- Small-molecule theranostic probes: a promising future in neurodegenerative diseases.International journal of cell biology · 2013Review
- Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells.PloS one · 2012Article
- Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions.Journal of virology · 2011Article
- Effect of transplantation of bone marrow-derived mesenchymal stem cells on mice infected with prions.Journal of virology · 2009Article
- Recent advances in prion chemotherapeutics.Infectious disorders drug targets · 2009Review
- Mechanistic insights into the cure of prion disease by novel antiprion compounds.Journal of virology · 2007Article
- Novel aspects of prions, their receptor molecules, and innovative approaches for TSE therapy.Cellular and molecular neurobiology · 2007Review
- Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models.Journal of virology · 2004Article
- Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent.Journal of virology · 2000Article
- Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation.Journal of virology · 2000Article
- Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures.Journal of virology · 2000Article
- Effectiveness of polyene antibiotics in treatment of transmissible spongiform encephalopathy in transgenic mice expressing Syrian hamster PrP only in neurons.Journal of virology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amphotericin B (AmB) is one of the few drugs able to prolong survival times in experimental scrapie and delays the accumulation of PrPres, a specific marker of this disease in the brain in vivo. Previous reports showed that the AmB effect is observed only if the drug is administered around the time of infection. In the present study, intracerebrally infected mice were treated with AmB or one of its derivatives, MS-8209, between 80 and 140 days postinoculation. We observed an increased incubation time and a delay in PrPres accumulation and glial fibrillary acidic protein gene expression. Treatment starting at 80 days postinoculation was as efficient as long-term treatment starting the day of inoculation. Our results indicate that polyene antibiotics may interfere, throughout the course of the experimental disease, with the propagation of the scrapie agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.