ArticleJournal of virology1997
Vaccination against persistent viral infection exacerbates CD4+ T-cell-mediated immunopathological disease.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Neutralizing antibody and T cell responses against SARS-CoV-2 variants of concern following ChAdOx-1 or BNT162b2 boosting in the elderly previously immunized with CoronaVac vaccine.Immunity & ageing : I & A · 2022Article
- The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection.Frontiers in immunology · 2020Article
- Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- IL-4 and IL-15 promotion of virtual memory CD8European journal of immunology · 2016Article
- Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells.Stem cells (Dayton, Ohio) · 2014Article
- Eliminating encephalitogenic T cells without undermining protective immunity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Mcl-1 antagonizes Bax/Bak to promote effector CD4(+) and CD8(+) T-cell responses.Cell death and differentiation · 2013Article
- CD4 T cell responses in latent and chronic viral infections.Frontiers in immunology · 2013Article
- Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.Journal of virology · 2012Article
- Hemophagocytosis causes a consumptive anemia of inflammation.The Journal of experimental medicine · 2011Article
- Cytolytic CD4(+) T cells in viral immunity.Expert review of vaccines · 2010Review
- Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection.Journal of neuroimmunology · 2010Article
- STAT5 is critical to maintain effector CD8+ T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of protozoan parasitic infections in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- MyD88 intrinsically regulates CD4 T-cell responses.Journal of virology · 2009Article
- Heterogeneous memory T cells in antiviral immunity and immunopathology.Viral immunology · 2008Review
- Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis.The Journal of experimental medicine · 2007Article
- Regulation of the interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cells.The Journal of biological chemistry · 2007Article
- Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory.European journal of immunology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Lymphocytic choriomeningitis virus (LCMV) infection of normal mice results in a fatal immunopathologic meningitis mediated by CD8+ cytotoxic T lymphocytes (CTL). We have previously shown that female beta2-microglobulin-deficient (beta2m-/-) mice, which are also deficient in CD8+ T cells, are susceptible to LCMV-induced immune-mediated meningitis, characterized by significant weight loss and mortality. This LCMV disease in beta2m-/- mice is mediated by CD4+ T lymphocytes. Our previous studies have also demonstrated that male beta2m-/- mice are less susceptible than female beta2m-/- mice to LCMV-induced, immune-mediated mortality and weight loss. In this report, we show that vaccination of male beta2m-/- mice enhances immunopathology following intracranial infection with LCMV. We observed increased production of gamma interferon (IFN-gamma), an increase in CD4+ CTL precursor frequency, and an increased frequency of IFN-gamma-producing cells from spleen cells of vaccinated male beta2m-/- mice. Vaccinated male beta2m-/- mice also had significantly increased inflammation in the cerebrospinal fluid (CSF), characterized by a large CD4+ T-cell infiltrate. CSF cells from vaccinated mice showed increased production of IFN-gamma on day 7 postchallenge. Neither vaccinated nor control beta2m-/- mice were able to clear virus, and the two groups had similarly high levels of virus early after infection. These results suggest that the magnitude of the early immune response is more important than the level of virus in the brain in determining the outcome of immunopathology in beta2m-/- mice. We show here that vaccination can increase CD4+ T-cell-dependent immunopathology to a persistent viral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.