Evidence map›Paper›PMID 9371596›Full record

ArticleJournal of virology1997

Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily.

X Yu, J E Mertz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

X YuMcArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706-1599, USA.
J E Mertz
University of Wisconsin–Madison · US

Funding

Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI WILLIAM M. SUGDEN · 1985 to 2026
$53.1M
STOREROOM AND MATERIALS ACQUISITION LABORATORYP30CA007175 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI DRINKWATER, NORMAN R. · 1985 to 2000
$2.4M
NCI NIH HHS CA07175NCI NIH HHS CA22443
6 · The paper itself

Abstract

Synthesis of the pre-C and pregenomic RNAs of human hepatitis B virus (HBV) is directed by two overlapping yet separate promoters (X. Yu and J. E. Mertz, J. Virol. 70:8719-8726, 1996). Previously, we reported the identification of a binding site for the nuclear receptor hepatocyte nuclear factor 4 (HNF4) spanning the TATA box-like sequence of the pre-C promoter. This HNF4-binding site consists of an imperfect direct repeat of the consensus half-site sequence 5'-AGGTCA-3' separated by one nucleotide; i.e., it is a DR1 hormone response element (HRE). We show here that other receptors, including chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1), human testicular receptor 2 (TR2), and peroxisome proliferator-activated receptors (PPARs) as heterodimers with retinoid X receptors (RXRs), can also specifically bind this DR1 HRE. Synthesis of the pre-C and pregenomic RNAs was affected both in transfected hepatoma cells and in a cell-free transcription system by the binding of factors to this DR1 HRE. Interestingly, whereas some members of the hormone receptor superfamily differentially repressed synthesis of the pre-C RNA (e.g., HNF4 and TR2) or activated synthesis of the pregenomic RNA (e.g., PPARgamma-RXRalpha), other members (e.g., COUP-TF1) coordinately repressed synthesis of both the pre-C and pregenomic RNAs. Thus, HBV likely regulates its expression and replication in part via this DR1 HRE. These findings indicate that appropriate ligands to nuclear receptors may be useful in the treatment of HBV infection.

Indexed as

Gene Expression Regulation, ViralBase SequenceBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCell-Free SystemCOUP Transcription Factor IDNA-Binding ProteinsGenome, ViralHepatitis B Core AntigensHepatitis B virusHepatocyte Nuclear Factor 4HumansMolecular Sequence DataNuclear ProteinsNuclear Receptor Subfamily 2, Group C, Member 1PhosphoproteinsPromoter Regions, GeneticBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCOUP Transcription Factor IDNA-Binding ProteinsHepatitis B Core AntigensHepatocyte Nuclear Factor 4MLX protein, humanNR2C1 protein, humanNR2F1 protein, humanNuclear ProteinsNuclear Receptor Subfamily 2, Group C, Member 1PhosphoproteinsProtein PrecursorsReceptors, Cytoplasmic and NuclearReceptors, Retinoic AcidReceptors, Thyroid HormoneRepressor ProteinsRetinoid X ReceptorsRNA PrecursorsRNA, ViralTranscription Factors

Identifiers

PMID9371596
PMCPMC230240
OpenAlexW1588851944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.