ArticleJournal of virology1997
Canine parvovirus host range is determined by the specific conformation of an additional region of the capsid.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 138 citations in OpenAlex.
- Molecular Detection and VP2 Characterization of Feline and Canine Parvoviruses in Domestic Cats in Central Vietnam.International journal of molecular sciences · 2026Article
- Delineated domain of VP2 capsid protein in H-1 parvovirus that determines susceptibility to human cancer cells.Journal of microbiology (Seoul, Korea) · 2026Article
- Detection and Molecular Characterisation ofViruses · 2026Article
- Genetic variability and phylogenetic analysis of the VP2 gene of feline parvovirus in Harbin.Frontiers in veterinary science · 2026Article
- Residues 27T and 297A in VP2 contribute to the enhanced replication and pathogenicity of raccoon dog parvovirus.Journal of virology · 2025Article
- Cross-species characterization of feline parvovirus and Feline-Origin canine parvovirus Southern China (2023-2024): insights into epidemiology, genetic evolution and recombination.BMC veterinary research · 2025Article
- Feline Panleukopenia Virus ZZ202303 Strain: Molecular Characterization and Structural Implications of theInternational journal of molecular sciences · 2025Article
- Rapid visual detection and differentiation of canine and feline parvovirus via a one-tube RPA-CRISPR/Cas13a assay.Frontiers in microbiology · 2025Article
- Epidemiological and Molecular Investigation of Feline Panleukopenia Virus Infection in China.Viruses · 2024Article
- First Isolation and Characterization of Feline Panleukopenia Virus From Wild Raccoon Dogs in the Residential Area of Shanghai, China.Veterinary medicine and science · 2024Article
- Evolutionary Dynamics and Pathogenicity Analysis of Feline Panleukopenia Virus in Xinjiang, China.Microorganisms · 2024Article
- Molecular Characterization of Feline Parvovirus from Domestic Cats in Henan Province, China from 2020 to 2022.Veterinary sciences · 2024Article
- Epidemiology, molecular prevalence and prevention on canine parvovirus in India: A review.Bioinformation · 2024Article
- China-origin G1 group isolate FPV072 exhibits higher infectivity and pathogenicity than G2 group isolate FPV027.Frontiers in veterinary science · 2024Article
- Isolation, cloning and analysis of parvovirus-specific canine antibodies from peripheral blood B cells.Developmental and comparative immunology · 2023Article
- Isolation of feline panleukopenia virus from Yanji of China and molecular epidemiology from 2021 to 2022.Journal of veterinary science · 2023Article
- Detection of Canine Parvovirus Type 2 by Designing Multiple Methods and Genetic Characterization in Iran.Archives of Razi Institute · 2022Article
- A canine-derived chimeric antibody with high neutralizing activity against canine parvovirus-2.AMB Express · 2022Article
- Article
- High-resolution asymmetric structure of a Fab-virus complex reveals overlap with the receptor binding site.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We analyzed a region of the capsid of canine parvovirus (CPV) which determines the ability of the virus to infect canine cells. This region is distinct from those previously shown to determine the canine host range differences between CPV and feline panleukopenia virus. It lies on a ridge of the threefold spike of the capsid and is comprised of five interacting loops from three capsid protein monomers. We analyzed 12 mutants of CPV which contained amino acid changes in two adjacent loops exposed on the surface of this region. Nine mutants infected and grew in feline cells but were restricted in replication in one or the other of two canine cell lines tested. Three other mutants whose genomes contain mutations which affect one probable interchain bond were nonviable and could not be propagated in either canine or feline cells, although the VP1 and VP2 proteins from those mutants produced empty capsids when expressed from a plasmid vector. Although wild-type and mutant capsids bound to canine and feline cells in similar amounts, infection or viral DNA replication was greatly reduced after inoculation of canine cells with most of the mutants. The viral genomes of two host range-restricted mutants and two nonviable mutants replicated to wild-type levels in both feline and canine cells upon transfection with plasmid clones. The capsids of wild-type CPV and two mutants were similar in susceptibility to heat inactivation, but one of those mutants and one other were more stable against urea denaturation. Most mutations in this structural region altered the ability of monoclonal antibodies to recognize epitopes within a major neutralizing antigenic site, and that site could be subdivided into a number of distinct epitopes. These results argue that a specific structure of this region is required for CPV to retain its canine host range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.