ArticleJournal of bacteriology1997
pCal, a highly unusual Ty1/copia retrotransposon from the pathogenic yeast Candida albicans.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Complex determinants of R-loop formation at transposable elements and major DNA satellites.Genetics · 2025Article
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- Natural Diversity of Heat-Induced Transcription of Retrotransposons in Arabidopsis thaliana.Genome biology and evolution · 2024Article
- A high-quality reference genome for the fission yeast Schizosaccharomyces osmophilus.G3 (Bethesda, Md.) · 2023Article
- Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective.Mobile DNA · 2020Review
- Superior ab initio identification, annotation and characterisation of TEs and segmental duplications from genome assemblies.PloS one · 2018Article
- A genome-wide transcriptome and translatome analysis ofGenome research · 2017Article
- Insertion of Retrotransposons at Chromosome Ends: Adaptive Response to Chromosome Maintenance.Frontiers in genetics · 2015Review
- The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans.Virulence · 2014Review
- Control of gag-pol gene expression in the Candida albicans retrotransposon Tca2.BMC molecular biology · 2007Article
- Characterization of the CaENG1 gene encoding an endo-1,3-beta-glucanase involved in cell separation in Candida albicans.Current microbiology · 2005Article
- Genomic evolution of the long terminal repeat retrotransposons in hemiascomycetous yeasts.Genome research · 2002Article
- An active retrotransposon in Candida albicans.Nucleic acids research · 2001Article
- Tca1, the retrotransposon-like element of Candida albicans, is a degenerate and inactive element.Journal of bacteriology · 1998Article
- Skipper, an LTR retrotransposon of Dictyostelium.Nucleic acids research · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retrotransposons are mobile genetic elements. They can transpose via the reverse transcription of mRNA into double-stranded DNA (dsDNA) followed by the insertion of this dsDNA into new sites within the host genome. The unintegrated, linear, dsDNA form of retrotransposons is usually very rare. We report here the isolation of a retrotransposon from Candida albicans which is unusual in this respect. This element, which we have named pCal, was first identified as a distinct band when uncut C. albicans DNA was examined on an agarose gel. Sequence analysis of the cloned element revealed that it is a retrotransposon belonging to the Ty1/copia group. It is estimated that pCal produces 50 to 100 free, linear, dsDNA copies of itself per cell. This is a much higher level of expression than even that of the system in which Ty1 is expressed behind the highly active GAL1 promoter on a high-copy-number plasmid (about 10 copies per cell). Another unusual feature of pCal is that its Pol enzymes are likely to be expressed via the pseudoknot-assisted suppression of an upstream, in-phase stop codon, as has been shown for Moloney murine leukemia virus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.