ArticleJournal of bacteriology1997
hetC, a gene coding for a protein similar to bacterial ABC protein exporters, is involved in early regulation of heterocyst differentiation in Anabaena sp. strain PCC 7120.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- Mutual interference of phosphorus starvation and diazotrophy in the cyanobacteria Nostoc sp. PCC 7120.Protoplasma · 2026Article
- Article
- Unravelling HetC as a peptidase-based ABC exporter driving functional cell differentiation in the cyanobacteriumMicrobiology spectrum · 2024Article
- Interaction network among factors involved in heterocyst-patterning in cyanobacteria.Molecular genetics and genomics : MGG · 2022Article
- The First Proteomics Study ofToxins · 2020Article
- The ABC Transporter Components HgdB and HgdC are Important for Glycolipid Layer Composition and Function of Heterocysts inLife (Basel, Switzerland) · 2018Article
- Three Substrains of the Cyanobacterium Anabaena sp. Strain PCC 7120 Display Divergence in Genomic Sequences andJournal of bacteriology · 2018Article
- ABC Transporter Required for Intercellular Transfer of Developmental Signals in a Heterocystous Cyanobacterium.Journal of bacteriology · 2015Article
- Article
- A major facilitator superfamily protein, HepP, is involved in formation of the heterocyst envelope polysaccharide in the cyanobacterium Anabaena sp. strain PCC 7120.Journal of bacteriology · 2012Article
- Directional RNA deep sequencing sheds new light on the transcriptional response of Anabaena sp. strain PCC 7120 to combined-nitrogen deprivation.BMC genomics · 2011Article
- Inactivation of a heterocyst-specific invertase indicates a principal role of sucrose catabolism in heterocysts of Anabaena sp.Journal of bacteriology · 2010Article
- Cyanobacterial heterocysts.Cold Spring Harbor perspectives in biology · 2010Review
- Compartmentalized function through cell differentiation in filamentous cyanobacteria.Nature reviews. Microbiology · 2010Review
- NtcA-regulated heterocyst differentiation genes hetC and devB from Anabaena sp. strain PCC 7120 exhibit a similar tandem promoter arrangement.Journal of bacteriology · 2009Article
- Expression and mutational analysis of the glnB genomic region in the heterocyst-forming Cyanobacterium Anabaena sp. strain PCC 7120.Journal of bacteriology · 2009Article
- Transcription activation by NtcA and 2-oxoglutarate of three genes involved in heterocyst differentiation in the cyanobacterium Anabaena sp. strain PCC 7120.Journal of bacteriology · 2008Article
- Signal transduction genes required for heterocyst maturation in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2006Article
- Epistasis analysis of four genes from Anabaena sp. strain PCC 7120 suggests a connection between PatA and PatS in heterocyst pattern formation.Journal of bacteriology · 2006Article
- Regulation by hetC of genes required for heterocyst differentiation and cell division in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposon-generated mutant C3 of Anabaena sp. strain PCC 7120 is unable to form heterocysts upon deprivation of combined nitrogen but forms a pattern of spaced, weakly fluorescent cells after 2 days of deprivation. Sequence analysis of chromosomal DNA adjacent to the ends of transposon Tn5-1058 in mutant C3 showed a 1,044-amino-acid open reading frame, designated hetC, whose predicted protein product throughout its C-terminal two-thirds has extensive similarity to the HlyB family of bacterial protein exporters. Its N-terminal third is unique and does not resemble any known protein. hetC lies 1,165 bp 5' from the previously described gene hetP. Reconstruction of the C3 mutation and its complementation in trans with a wild-type copy of hetC confirmed that hetC has an essential regulatory role early in heterocyst development. hetC is induced ca. 4 h after nitrogen stepdown, hours after induction of hetR. Expression of hetC depends on HetR and may depend on HetC. Highly similar sequences are present 5' from the initiation codons and in the 3' untranslated regions of hetC and of two heterocyst-specific genes, devA and hetP.
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