ArticleAntimicrobial agents and chemotherapy1997
Macrolide resistance in Helicobacter pylori: mechanism and stability in strains from clarithromycin-treated patients.
Article in Antimicrobial agents and chemotherapy, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Detection of Clarithromycin Resistance in Helicobacter pylori Using the AllplexTM H. pylori & ClariR Assay and the Ezplex® HP-CLA Real-Time PCR Kit.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- Quantitative multiplex real-time polymerase chain reaction assay for the detection of Helicobacter pylori and clarithromycin resistance.BMC microbiology · 2023Article
- Real-Time Polymerase Chain Reaction for the Detection ofGut and liver · 2023Article
- Antibiotic Susceptibility and Clarithromycin Resistance Determinants inAntibiotics (Basel, Switzerland) · 2023Article
- BestAntibiotics (Basel, Switzerland) · 2020Review
- Genotypic and Phenotypic Resistance to Clarithromycin inJournal of clinical medicine · 2020Article
- Trends inMicrobial genomics · 2020Review
- Expanding the Scope of Protein Synthesis Using Modified Ribosomes.Journal of the American Chemical Society · 2019Article
- Clinical relevance of point mutations in the 23S rRNA gene in Helicobacter pylori eradication: A prospective, observational study.Medicine · 2018Observational
- Resistance to Macrolide Antibiotics in Public Health Pathogens.Cold Spring Harbor perspectives in medicine · 2016Review
- Antimicrobial susceptibility and clarithromycin resistance patterns of Helicobacter pylori clinical isolates in Vietnam.F1000Research · 2016Article
- Clarithromycin-based standard triple therapy can still be effective for Helicobacter pylori eradication in some parts of the Korea.Journal of Korean medical science · 2014Article
- Frequency of antibiotic resistance in Helicobacter pylori strains isolated from the northern population of Iran.Journal of microbiology (Seoul, Korea) · 2011Article
- Mechanisms of Helicobacter pylori antibiotic resistance: An updated appraisal.World journal of gastrointestinal pathophysiology · 2011Article
- Detection of A2142C, A2142G, and A2143G Mutations in 23s rRNA Gene Conferring Resistance to Clarithromycin among Helicobacter pylori Isolates in Kerman, Iran.Iranian journal of medical sciences · 2011Article
- Characterization of clarithromycin resistance in isolates of Helicobacter pylori from the UAE.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2010Article
- Antimicrobial susceptibility and mutations involved in clarithromycin resistance in Helicobacter pylori isolates from patients in the western central region of Colombia.Antimicrobial agents and chemotherapy · 2009Article
- Who's Winning the War? Molecular Mechanisms of Antibiotic Resistance in Helicobacter pylori.Current drug therapy · 2008Article
- Quadruplex real-time PCR assay using allele-specific scorpion primers for detection of mutations conferring clarithromycin resistance to Helicobacter pylori.Journal of clinical microbiology · 2008Article
- Helicobacter pylori in Dyspepsia - Antibiotic Sensitivity and Virulence Patterns.Medical journal, Armed Forces India · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori strains from seven patients treated with clarithromycin were investigated for development, mechanism, and stability of resistance. Genetic relatedness between pre- and posttreatment isolates was shown by arbitrary primed PCR. Clarithromycin resistance was associated with A-to-G transitions at either position 2143 or 2144 or at both positions 2116 and 2142. In four cases, the mutations were homozygous. The Cla(r) phenotype was stable after 50 subcultivations in vitro. No erythromycin-modifying enzymes or rRNA methylases were found by biological assays, PCR and sequencing, or cloning methods.
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