ArticleAntimicrobial agents and chemotherapy1997
Characterization of fluoroquinolone-induced Achilles tendon toxicity in rats: comparison of toxicities of 10 fluoroquinolones and effects of anti-inflammatory compounds.
Article in Antimicrobial agents and chemotherapy, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Too Much of a Good Thing: Defining Antimicrobial Therapeutic Targets to Minimize Toxicity.Clinical pharmacology and therapeutics · 2021Pooled it
- Article
- Fluoroquinolone-Mediated Tendinopathy and Tendon Rupture.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The fluoroquinolones may positively affect tendon healing after surgical repair.Joint diseases and related surgery · 2024Article
- Article
- Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats.Antimicrobial agents and chemotherapy · 2022Article
- Delafloxacin: Place in Therapy and Review of Microbiologic, Clinical and Pharmacologic Properties.Infectious diseases and therapy · 2018Review
- TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells.BMC complementary and alternative medicine · 2015Article
- Work related etiology of de Quervain's tenosynovitis: a case-control study with prospectively collected data.BMC musculoskeletal disorders · 2015Article
- Stochastic mechanical degradation of multi-cracked fiber bundles with elastic and viscous interactions.The European physical journal. E, Soft matter · 2015Article
- Bilateral spontaneous non-traumatic rupture of the Achilles tendon: a case report.Journal of medical case reports · 2011Article
- Drug-versus-drug adverse event rate comparisons: a pilot study based on data from the US FDA Adverse Event Reporting System.Drug safety · 2009Article
- The effects of enrofloxacin on canine tendon cells and chondrocytes proliferation in vitro.Veterinary research communications · 2008Article
- Spontaneous bilateral Achilles tendon rupture in a patient treated with oral levofloxacin.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2007Article
- [Bilateral Achilles tendinitis as adverse reaction to levofloxacine. Concerning a case].Atencion primaria · 2003Article
- Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen.Antimicrobial agents and chemotherapy · 2000Article
- Ultrastructure of Achilles tendons of rats treated with ofloxacin and fed a normal or magnesium-deficient diet.Antimicrobial agents and chemotherapy · 2000Article
- Association Between Third-Generation Fluoroquinolones and Achilles Tendon Rupture: A Self-Controlled Case Series Analysis.Annals of family medicineArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Fluoroquinolone antibacterial agents have been reported to induce tendon lesions in juvenile rats. In the present study, we characterized fluoroquinolone-induced Achilles tendon lesions by comparing the effects of 10 fluoroquinolones and examining the potential of one of these antimicrobial agents, pefloxacin, to induce tendon lesions when coadministered with one of nine anti-inflammatory compounds. Among the 10 fluoroquinolones tested, fleroxacin and pefloxacin were the most toxic, inducing lesions at a dose of 100 mg/kg of body weight or more, while lomefloxacin, levofloxacin, and ofloxacin or sparfloxacin and enoxacin induced lesions at 300 mg/kg or more and 900 mg/kg, respectively. In contrast, norfloxacin, ciprofloxacin, and tosufloxacin had no effect even at the high dose of 900 mg/kg. The severity of the Achilles tendon lesions appeared to correlate with the structure of the substituent at the seventh position. Furthermore, pefloxacin-induced tendon lesions were inhibited by coadministration with dexamethasone and N-nitro-L-arginine methyl ester. Phenidone (1-phenyl-3-pyrazolidinone) and 2-(12-hydroxydodeca-5,10-diynyl)3,5,6-trimethyl-1,4-benzoqui none (AA861) also decreased the incidence of tendon lesions. In contrast, catalase, dimethyl sulfoxide, indomethacin, pyrilamine, and cimetidine did not modify these tendon lesions. These results suggest that nitric oxide and 5-lipoxigenase products partly mediate fluoroquinolone-induced tendon lesions.
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