ArticleBiophysical journal1997
Viscoelastic response of fibroblasts to tension transmitted through adherens junctions.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
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- Measurement of in-plane elasticity of live cell layers using a pressure sensor embedded microfluidic device.Scientific reports · 2016Article
- Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation.Scientific reports · 2016Article
- Multiscale mechanobiology: mechanics at the molecular, cellular, and tissue levels.Cell & bioscience · 2013Article
- Barrier-protective effects of activated protein C in human alveolar epithelial cells.PloS one · 2013Article
- Continuum modeling and numerical simulation of cell motility.Journal of mathematical biology · 2012Article
- Dynamics of Microvillus Extension and Tether Formation in Rolling Leukocytes.Cellular and molecular bioengineering · 2009Article
- Oncogenic Ras-transformed human fibroblasts exhibit differential changes in contraction and migration in 3D collagen matrices.Experimental cell research · 2008Article
- Nanomechanical characterization of red blood cells using optical tweezers.Journal of materials science. Materials in medicine · 2008Article
- Agnostic particle tracking for three-dimensional motion of cellular granules and membrane-tethered bead dynamics.Biophysical journal · 2008Article
- Transport of a 1D viscoelastic actin-myosin strip of gel as a model of a crawling cell.Physica A · 2006Article
- Myofibroblast development is characterized by specific cell-cell adherens junctions.Molecular biology of the cell · 2004Article
- Quantitative analysis of the viscoelastic properties of thin regions of fibroblasts using atomic force microscopy.Biophysical journal · 2004Article
- Micromechanical mapping of live cells by multiple-particle-tracking microrheology.Biophysical journal · 2002Article
- Cell sorting is analogous to phase ordering in fluids.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mechanics of living cells measured by laser tracking microrheology.Biophysical journal · 2000Article
- Measurement of local viscoelasticity and forces in living cells by magnetic tweezers.Biophysical journal · 1999Article
- Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein.The Journal of cell biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytoplasmic deformation was monitored by observing the displacements of 200-nm green fluorescent beads microinjected into the cytoplasm of Swiss 3T3 fibroblasts. We noted a novel protrusion of nonruffling cell margins that was accompanied by axial flow of beads and cytoplasmic vesicles as far as 50 microm behind the protruding plasma membrane. Fluorescent analog cytochemistry and immunofluorescence localization of F-actin, alpha-actinin, N-cadherin, and beta-catenin showed that the protruding margins of deforming cells were mechanically coupled to neighboring cells by adherens junctions. Observations suggested that protrusion resulted from passive linear deformation in response to tensile stress exerted by centripetal contraction of the neighboring cell. The time dependence of cytoplasmic strain calculated from the displacements of beads and vesicles was fit quantitatively by a Kelvin-Voight model for a viscoelastic solid with a mean limiting strain of 0.58 and a mean strain rate of 4.3 x 10(-3) s(-1). In rare instances, the deforming cell and its neighbor spontaneously became uncoupled, and recoil of the protruding margin was observed. The time dependence of strain during recoil also fit a Kelvin-Voight model with similar parameters, suggesting that the kinetics of deformation primarily reflect the mechanical properties of the deformed cell rather than the contractile properties of its neighbor. The existence of mechanical coupling between adjacent fibroblasts through adherens junctions and the viscoelastic responses of cells to tension transmitted directly from cell to cell are factors that must be taken into account to fully understand the role of fibroblasts in such biological processes as wound closure and extracellular matrix remodeling during tissue development.
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