ArticleFEBS letters1997
Interaction of SecB with soluble SecA.
Article in FEBS letters, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- The way is the goal: how SecA transports proteins across the cytoplasmic membrane in bacteria.FEMS microbiology letters · 2018Review
- The Sec System: Protein Export inEcoSal Plus · 2017Review
- Determination of the intracellular concentration of the export chaperone SecB in Escherichia coli.PloS one · 2017Article
- Multitasking SecB chaperones in bacteria.Frontiers in microbiology · 2014Review
- Characterization of the Escherichia coli SecA signal peptide-binding site.Journal of bacteriology · 2012Article
- Assembly of the translocase motor onto the preprotein-conducting channel.Molecular microbiology · 2008Article
- Selective photoaffinity labeling identifies the signal peptide binding domain on SecA.Journal of molecular biology · 2007Article
- Probing the affinity of SecA for signal peptide in different environments.Biochemistry · 2005Article
- Sites of interaction between SecA and the chaperone SecB, two proteins involved in export.Protein science : a publication of the Protein Society · 2004Article
- Biophysical characterization of the influence of salt on tetrameric SecB.Biophysical journal · 2001Article
- Overproduction of SecA suppresses the export defect caused by a mutation in the gene encoding the Escherichia coli export chaperone secB.Journal of bacteriology · 1999Article
- Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope.Microbiology and molecular biology reviews : MMBR · 1999Review
- Protein targeting to the bacterial cytoplasmic membrane.Microbiology and molecular biology reviews : MMBR · 1999Review
- secG and temperature modulate expression of azide-resistant and signal sequence suppressor phenotypes of Escherichia coli secA mutants.Journal of bacteriology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The preprotein binding molecular chaperone SecB functions by preventing the premature folding of the preprotein in the cytosol, and targeting it to the peripheral subunit SecA of the translocase at the cytoplasmic membrane. The nature of the interaction of SecB with soluble SecA was studied by fluorescence anisotropy spectroscopy of Ru(bpy)2(dcbpy)-labeled SecA in the presence of increasing concentrations of SecB. A more than 50-fold difference in affinity for the cytosolic SecA compared to translocase associated SecA seems to prevent unproductive binding of SecB to the cytosolic SecA and stresses its targeting function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.