ArticleGenes & development1997
Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed.
Article in Genes & development, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed, 238 citations in OpenAlex.
- Article
- Transcriptional control of embryonic and adult neural progenitor activity.Frontiers in neuroscience · 2023Review
- T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development.Frontiers in cell and developmental biology · 2021Review
- Mechanisms Underlying Hox-Mediated Transcriptional Outcomes.Frontiers in cell and developmental biology · 2021Review
- TheFrontiers in neural circuits · 2021Review
- Limited Availability of General Co-Repressors Uncovered in an Overexpression Context during Wing Venation inGenes · 2020Article
- The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development.Nature immunology · 2020Article
- The transcription factor NKX2-2 regulates oligodendrocyte differentiation through domain-specific interactions with transcriptional corepressors.The Journal of biological chemistry · 2020Article
- The C-terminal WD40 repeats on the TOPLESS co-repressor function as a protein-protein interaction surface.Plant molecular biology · 2019Article
- Article
- Chimeric NANOG repressors inhibit glioblastoma growth in vivo in a context-dependent manner.Scientific reports · 2019Article
- Exploiting regulatory heterogeneity to systematically identify enhancers with high accuracy.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Notch repressor complex in Drosophila: in vivo analysis of Hairless mutants using overexpression experiments.Development genes and evolution · 2019Article
- Inference of Transcription Factor Regulation Patterns Using Gene Expression Covariation in Natural Populations ofBiophysics · 2018Article
- A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.Science advances · 2017Article
- A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer.PLoS genetics · 2017Article
- Homeodomain proteins: an update.Chromosoma · 2016Review
- Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.Science advances · 2015Article
- The Groucho/Transducin-like enhancer of split protein family in animal development.IUBMB life · 2015Review
- Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1.Genes & development · 2015Article
35 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relatively little is known about the molecular mechanisms involved in transcriptional repression, despite its importance in development and differentiation. Recent evidence suggests that some transcriptional repressors act by way of adaptor molecules known as corepressors. Here, we use in vivo functional assays to test whether different repressor activities are mediated by the Groucho (Gro) corepressor in the Drosophila embryo. Previously, Gro was proposed to mediate repression by the Hairy-related family of basic helix-loop-helix proteins. Our results indicate not only that repression by Hairy requires Gro, but that a repressor domain from the Engrailed (En) homeodomain protein is also Gro dependent. The latter result correlates with an ability of this En domain to bind to Gro in vitro. In contrast, repressor regions from the Even-skipped, Snail, Krüppel, and Knirps transcription factors are effective in the absence of Gro. These results show that Gro is not generally required for repression, but acts as a specific corepressor for a fraction of negative regulators, including Hairy and En.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.