ArticleClinical and experimental immunology1997
Specificities of anti-neutrophil autoantibodies in patients with rheumatoid arthritis (RA).
Article in Clinical and experimental immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- MPO-ANCA-associated necrotizing glomerulonephritis in rheumatoid arthritis; a case report and review of literature.Journal of nephropathology · 2017Article
- Onset of Microscopic Polyangiitis in Binephrectomied Patient on Chronic Hemodialysis-Case Report.Frontiers in immunology · 2017Article
- Citrullination in Rheumatoid Arthritis-A Process Promoted by Neutrophil Lysis?Rambam Maimonides medical journal · 2016Review
- Does searching for antineutrophil cytoplasmic antibodies help with the diagnosis of Adult-onset Still's disease?Rheumatology international · 2013Article
- Naturally occurring anti-band 3 antibodies in clearance of senescent and oxidatively stressed human red blood cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2012Article
- Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.Rheumatology international · 2005Article
- High prevalence of autoantibodies among Danish centenarians.Clinical and experimental immunology · 2004Article
- Autoantibodies in vasculitis.Arthritis research & therapy · 2003Review
- Methods for the detection of anti-neutrophil cytoplasmic antibodies. Recommendations for clinical use of ANCA serology and laboratory efforts to optimize the informative value of ANCA test results.Springer seminars in immunopathology · 2001Review
- Characterisation of autoantibodies to neutrophil granule constituents among patients with reactive arthritis, rheumatoid arthritis, and ulcerative colitis.Annals of the rheumatic diseases · 2000Article
- Churg-Strauss syndrome.Thorax · 2000Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to characterize antigens recognized by neutrophil-specific autoantibodies from patients with RA. Sera from 62 RA patients were screened by indirect immunofluorescence (IIF). Positive sera were further tested by ELISAs for antibodies against various granule proteins and by immunoblotting of electrophoretically separated cell, granule or nuclear extracts. Forty-two sera (68%) reacted with ethanol-fixed neutrophils. In the ELISAs 32% of the 28 medium to strongly IIF-positive sera were negative, while 43% were weakly positive for more than one antigen. Immunoblots of whole neutrophils showed IgG reactions at 25-35 kD, in the 55-kD region, at 80 kD, and at 110 kD. Most sera reacted with more than one band. Except for the 55-kD antigen, none of the antigens appeared in lymphocytes. The most notable reactivity in subcellular fractions was with lactoferrin and with bands of 25-35 kD from nuclei. In conclusion, anti-neutrophil autoantibodies from RA patients recognize different antigens in the cytoplasm and in the nucleus. Lactoferrin is one of the common antigens recognized, but also unknown nuclear antigens of 25-35 kD mol. wt are involved.
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