ArticleThe Journal of physiology1997
Action potential propagation into the presynaptic dendrites of rat mitral cells.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.The Journal of physiology · 2026Article
- Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials.Neuroscience bulletin · 2022Article
- Sparse connectivity for MAP inference in linear models using sister mitral cells.PLoS computational biology · 2022Article
- Article
- Robustness to Axon Initial Segment Variation Is Explained by Somatodendritic Excitability in Rat Substantia Nigra Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Diversity of Axonal and Dendritic Contributions to Neuronal Output.Frontiers in cellular neuroscience · 2019Article
- Variable Action Potential Backpropagation during Tonic Firing and Low-Threshold Spike Bursts in Thalamocortical But Not Thalamic Reticular Nucleus Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Synchrony and so much more: Diverse roles for electrical synapses in neural circuits.Developmental neurobiology · 2017Review
- Subcellular Patch-clamp Recordings from the Somatodendritic Domain of Nigral Dopamine Neurons.Journal of visualized experiments : JoVE · 2016Article
- Is realistic neuronal modeling realistic?Journal of neurophysiology · 2016Review
- Control of Mitral/Tufted Cell Output by Selective Inhibition among Olfactory Bulb Glomeruli.Neuron · 2016Article
- Odor Experience Facilitates Sparse Representations of New Odors in a Large-Scale Olfactory Bulb Model.Frontiers in neuroanatomy · 2016Article
- Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.The Journal of comparative neurology · 2015Article
- Tonic firing rate controls dendritic Ca2+ signaling and synaptic gain in substantia nigra dopamine neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- General features of the retinal connectome determine the computation of motion anticipation.eLife · 2015Article
- Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease.Neuroscience · 2015Article
- Supralinear dendritic Ca(2+) signalling in young developing CA1 pyramidal cells.The Journal of physiology · 2014Article
- Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Discharge patterning in rat olfactory bulb mitral cells in vivo.Physiological reports · 2014Article
- Electrical responses of three classes of granule cells of the olfactory bulb to synaptic inputs in different dendritic locations.Frontiers in computational neuroscience · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Dendritic patch-clamp recordings were obtained from mitral cells in rat olfactory bulb slices, up to 350 microns from the soma. Simultaneous dendritic and somatic whole-cell recordings indicated that action potentials (APs) evoked by somatic or dendritic current injection were initiated near the soma. Both the large amplitude (100.7 +/- 1.1 mV) and the short duration (1.38 +/- 0.07 ms) of the AP were maintained as the AP propagated back into the primary mitral cell dendrites. 2. Outside-out patches isolated from mitral cell dendrites contained voltage-gated Na+ channels (peak conductance density, 90 pS micron-2 at -10 mV). When an AP was used as a somatic voltage-clamp command in the presence of 1 microM tetrodotoxin (TTX), the amplitude of the dendritic potential was attenuated to 48 +/- 14 mV. This shows that dendritic Na+ channels support the active back-propagation of APs. 3. Dendritic patches contained voltage-gated K+ channels with high density (conductance density, 513 pS micron-2 at 30 mV). Dendritic K+ currents were reduced to 35% by 1 mM external tetraethylammonium chloride (TEACl). When an AP was used as a somatic voltage-clamp command in the presence of TEACl, the dendritic potential was markedly prolonged. This indicates that dendritic K+ channels mediate the fast repolarization of dendritic APs. 4. We conclude that voltage-gated Na+ and K+ channels support dendritic APs with large amplitudes and short durations that may trigger fast transmitter release at dendrodendritic synapses in the olfactory bulb.
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