ArticleThe Journal of physiology1997
Endothelium-dependent frequency modulation of Ca2+ signalling in individual vascular smooth muscle cells of the rat.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields.Nanoscale advances · 2024Article
- The Role of Endothelial CaInternational journal of molecular sciences · 2018Review
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Article
- Benefit of SERCA2a gene transfer to vascular endothelial and smooth muscle cells: a new aspect in therapy of cardiovascular diseases.Current vascular pharmacology · 2013Review
- Calcium signaling in smooth muscle.Cold Spring Harbor perspectives in biology · 2011Review
- Agonist-evoked Ca(2+) wave progression requires Ca(2+) and IP(3).Journal of cellular physiology · 2010Article
- Nitric oxide induces airway smooth muscle cell relaxation by decreasing the frequency of agonist-induced Ca2+ oscillations.The Journal of general physiology · 2010Article
- Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Role of the endothelium on arterial vasomotion.Biophysical journal · 2005Article
- Vasomotion: cellular background for the oscillator and for the synchronization of smooth muscle cells.British journal of pharmacology · 2005Review
- Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries.The Journal of physiology · 2004Article
- Purinergic and adrenergic Ca2+ transients during neurogenic contractions of rat mesenteric small arteries.The Journal of physiology · 2003Article
- Simultaneous imaging of Ca2+ signals in interstitial cells of Cajal and longitudinal smooth muscle cells during rhythmic activity in mouse ileum.The Journal of physiology · 2002Article
- Simultaneous measurements of changes in sarcoplasmic reticulum and cytosolic.The Journal of physiology · 2001Article
- Dynamic Ca2+ signalling in rat arterial smooth muscle cells under the control of local renin-angiotensin system.The Journal of physiology · 1999Article
- Local and cellular Ca2+ transients in smooth muscle of pressurized rat resistance arteries during myogenic and agonist stimulation.The Journal of physiology · 1999Article
- Radial localization of inositol 1,4,5-trisphosphate-sensitive Ca2+ release sites in Xenopus oocytes resolved by axial confocal linescan imaging.The Journal of general physiology · 1999Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We visualized intracellular Ca2+ concentration ([Ca2+]i) changes, using fluo-3 as an indicator, of individual vascular smooth muscle cells and endothelial cells within intact rat tail arteries by confocal microscopy. 2. Using a piezo-driven objective, we focused on endothelial and smooth muscle cell layers alternately to obtain Ca2+ images of their cells. In the presence of 1 microM acetylcholine (ACh), individual endothelial cells responded with intermittent increases in the [Ca2+]i (Ca2+ oscillations). At the same time, the frequency of Ca2+ oscillations in smooth muscle cells induced by electrical stimulation of the perivascular sympathetic nerve was greatly decreased. 3. A [Ca2+]i rise during the oscillations in the endothelial cells propagated in the form of a wave along the long axis of the cells. 4. In the presence of a NO synthase inhibitor, no significant inhibitory effect of ACh on the Ca2+ signalling in the vascular smooth muscle cells was detected, although the Ca2+ oscillations in the endothelial cells persisted. 5. The inhibitory effect of ACh on the frequency of Ca2+ oscillations in the vascular smooth muscle cells was mimicked by 1 microM sodium nitroprusside, a NO donor. 6. These results indicate that Ca2+ waves and oscillations in vascular endothelial cells regulate NO production, which modulates vascular tone by decreasing the frequency of Ca2+ oscillations in smooth muscle cells activated by sympathetic agonists.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.