ArticleBritish journal of cancer1997
Can cancer cells transform normal host cells into malignant cells?
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- The clinical problem of Bell's palsy: is treatment with steroids effective?The British journal of general practice : the journal of the Royal College of General Practitioners · 1996Pooled it
- Spontaneous Fusion with Transformed Mesenchymal Stromal Cells Results in Complete Heterogeneity in Prostate Cancer Cells.Cancers · 2024Article
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- Role of prostate and bone stromal cells on prostate cancer progression.American journal of clinical and experimental urology · 2022Review
- Cancer cell's neuroendocrine feature can be acquired through cell-cell fusion during cancer-neural stem cell interaction.Scientific reports · 2020Article
- Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics.Asian journal of urology · 2019Review
- Cultured circulating tumor cells and their derived xenografts for personalized oncology.Asian journal of urology · 2016Review
- Regulation of prostate cancer progression by the tumor microenvironment.Cancer letters · 2016Review
- Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics.Oncotarget · 2015Article
- Prostate cancer metastasis: roles of recruitment and reprogramming, cell signal network and three-dimensional growth characteristics.Translational andrology and urology · 2015Review
- Experimental research of host macrophage canceration induced by glioma stem progenitor cells.Molecular medicine reports · 2015Article
- Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.PloS one · 2015Article
- RANK-mediated signaling network and cancer metastasis.Cancer metastasis reviews · 2014Review
- RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization.Endocrine-related cancer · 2014Article
- Animal models and the tumor microenvironment: studies of tumor-host symbiosis.Seminars in oncology · 2014Review
- In-vivo fusion of human cancer and hamster stromal cells permanently transduces and transcribes human DNA.PloS one · 2014Article
- From Reductionism to Holism: Systems-oriented Approaches in Cancer Research.Global advances in health and medicine · 2012Article
- Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts.BMC biotechnology · 2011Article
- Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells.European urology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A human prostate tumour cell line, LNCaP C4-2, when injected into athymic male nude mice, produced tumours containing: (1) only human cancer cells similar to those injected; (2) only murine stromal cells containing abnormal chromosome constitutions; or (3) both human prostate cancer cells similar to those injected and the transformed murine stromal cells with altered chromosome constitutions. Karyotypic analysis of murine metaphases from all the host-derived tumours showed mostly pseudodiploid chromosome constitutions, with multiple copies (amplification) of mouse chromosome 15 and the absence of a typical Y chromosome. Fluorescence in situ hybridization analysis of these murine cells, using a biotin-labelled total human DNA painting probe, further demonstrated the absence of human DNA and the presence of only mouse metaphase and interphase cells in these transformed stromal cells. These results suggest that cancer cells are capable of inducing neoplastic transformation in stromal cells of the host organ by some, as yet unknown, epigenetic mechanism(s).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.