ArticleDigestive diseases and sciences1997
Salivary epidermal growth factor plays a role in protection of ileal mucosal integrity.
Article in Digestive diseases and sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 44 citations in OpenAlex.
- Influence of Electronic Cigarettes on Antioxidant Capacity and Nucleotide Metabolites in Saliva.Toxics · 2021Article
- The Antimicrobial Peptide Nal-P-113 Exerts a Reparative Effect by Promoting Cell Proliferation, Migration, and Cell Cycle Progression.BioMed research international · 2018Article
- Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome.World journal of gastroenterology · 2014Article
- Submandibular salivary glands: influence on growth rate and life span in mice.Journal of physiology and biochemistry · 2011Article
- Antioxidant profile of whole saliva after scaling and root planing in periodontal disease.Journal of periodontal & implant science · 2010Article
- The oral cavity and age: a site of chronic inflammation?PloS one · 2007Article
- Article
- Acute stress-induced tissue injury in mice: differences between emotional and social stress.Cell stress & chaperones · 2002Article
- Inhibition of DNA synthesis in Caco-2 cells by oxidative stress: amelioration by epidermal growth factor.Digestive diseases and sciences · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The role of salivary epidermal growth factor (EGF) in the maintenance of ileal mucosal integrity was studied by evaluating the effects of sialoadenectomy on luminal EGF levels, ileal tissue resistance (Rt), and unidirectional flux of [51Cr]EDTA. Mice in groups 1 (SLX) and 2 (SLX + EGF) were subjected to sialoadenectomy, while mice in groups 3 (Sham) and 4 (Sham + EGF) underwent a sham procedure. All animals received normal diet and water, except that EGF (100 ng/ml) was added to water for SLX + EGF and Sham + EGF mice. At seven days after surgery, luminal EGF levels in gastrointestinal segments and ileal Rt were significantly reduced by sialoadenectomy, which was prevented by EGF supplementation. Unidirectional flux of [51Cr]EDTA was 6- to 22-fold greater in the ileum of sialoadenectomized mice, which was prevented by EGF administration. Results suggest that salivary EGF may be the major source of intestinal EGF, and it may play a role in maintenance of ileal mucosal integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.