ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Modulation of rod photoreceptor cyclic nucleotide-gated channels by tyrosine phosphorylation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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Who cites it
53 citing papers in PubMed, 114 citations in OpenAlex.
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- Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type.bioRxiv : the preprint server for biology · 2023Article
- The gating mechanism in cyclic nucleotide-gated ion channels.Scientific reports · 2018Article
- Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.The Journal of biological chemistry · 2016Article
- Allosteric proteins as logarithmic sensors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Effect of knocking down the insulin receptor on mouse rod responses.Scientific reports · 2015Article
- Adaptive potentiation in rod photoreceptors after light exposure.The Journal of general physiology · 2014Article
- Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.Biochemistry · 2013Article
- A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channels.The Journal of biological chemistry · 2013Article
- Insulin receptor regulates photoreceptor CNG channel activity.American journal of physiology. Endocrinology and metabolism · 2012Article
- Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels.Nature communications · 2011Article
- Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide-gated channels.The Journal of general physiology · 2011Article
- Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.EMBO reports · 2010Article
- Circadian regulation of ion channels and their functions.Journal of neurochemistry · 2009Review
- How vision begins: an odyssey.Proceedings of the National Academy of Sciences of the United States of America · 2008Review
- Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Tyrosine phosphorylation of cGMP-gated ion channels is under circadian control in chick retina photoreceptors.Investigative ophthalmology & visual science · 2007Article
- Effects of the protein tyrosine kinase inhibitor genistein and taurine on retinal function in isolated superfused retina.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007Article
- Cyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition.The Journal of general physiology · 2006Article
- Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins.Journal of cardiovascular pharmacology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cyclic nucleotide-gated (CNG) channels in vertebrate photoreceptors are crucial for transducing light-induced changes in cGMP concentration into electrical signals. In this study, we show that both native and exogenously expressed CNG channels from rods are modulated by tyrosine phosphorylation. The cGMP sensitivity of CNG channels, composed of rod alpha-subunits expressed in Xenopus oocytes, gradually increases after excision of inside-out patches from the oocyte membrane. This increase in sensitivity is inhibited by a protein tyrosine phosphatase (PTP) inhibitor and is unaffected by three different Ser/Thr phosphatase inhibitors. Moreover, it is suppressed or reversed by application of ATP but not by a nonhydrolyzable ATP analog. Application of protein tyrosine kinase (PTK) inhibitors causes an increase in cGMP sensitivity, but only in the presence of ATP. Taken together, these results suggest that CNG channels expressed in oocytes are associated with active PTK(s) and PTP(s) that regulate their cGMP sensitivity by changing phosphorylation state. The cGMP sensitivity of native CNG channels from salamander rod outer segments also increases and decreases after incubation with inhibitors of PTP(s) and PTK(s), respectively. These results suggest that rod CNG channels are modulated by tyrosine phosphorylation, which may function as a novel mechanism for regulating the sensitivity of rods to light.
Indexed as
Identifiers
9364053PMC6573590W1551182340What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.