ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Dendroaxonal transcytosis of transferrin in cultured hippocampal and sympathetic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Proteomics signatures associated with cognitive trajectories: evidence from the English Longitudinal Study of Ageing.medRxiv : the preprint server for health sciences · 2026Article
- Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3.The Journal of cell biology · 2022Article
- NgCAM and VAMP2 reveal that direct delivery and dendritic degradation maintain axonal polarity.Molecular biology of the cell · 2022Article
- Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body.PLoS pathogens · 2016Article
- Iron homeostasis in peripheral nervous system, still a black box?Antioxidants & redox signaling · 2014Review
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- BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density during LTP via a Rab11-dependent pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Forward transport of proteins in the plasma membrane of migrating cerebellar granule cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s.Journal of cellular and molecular medicine · 2011Article
- The role of endosomal-recycling in long-term potentiation.Cellular and molecular life sciences : CMLS · 2011Review
- Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Iron is essential for neuron development and memory function in mouse hippocampus.The Journal of nutrition · 2009Article
- The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM.The Journal of cell biology · 2008Article
- Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling.Molecular biology of the cell · 2006Article
- Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Receptor activation and homer differentially control the lateral mobility of metabotropic glutamate receptor 5 in the neuronal membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Sorting of internalized neurotrophins into an endocytic transcytosis pathway via the Golgi system: Ultrastructural analysis in retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies using overexpressed polymeric immunoglobulin receptor in cultured neurons have suggested that these cells may use a dendroaxonal transcytotic pathway (Ikonen et al., 1993; de Hoop et al., 1995). By using a combination of semiquantitative light microscopy, video microscopy, and a biochemical assay, we show that this pathway is used by the endogenous ligand transferrin (Tf) and its receptor. Labeled Tf added to fully mature hippocampal neurons changes the intracellular distribution of its receptor from preferentially dendritic shortly after addition to dendritic and axonal at longer times. Incubation of living neurons with (caged)FITC-Tf followed by uncaging in the dendrites results in the later appearance of fluorescence in the axon of the same cell. In "chambered" sympathetic neurons in culture, 125I-Tf or iron as 55Fe-Tf added to the cell body/dendrite chamber is recovered in the axonal chamber, showing that internalized ligand from the cell body-dendrite area is released at the axonal end. Finally, we show that excitatory neurotransmitters increase Tf receptor transcytosis, whereas inhibitory neurotransmitters reduce it. The dendritic uptake, transcytotic transport, and axonal release of physiologically active Tf demonstrated here could be envisioned for other trophic factors and therefore have important consequences for neuronal anterograde target maturation. Moreover, the changes in transcytosis after neurotransmitter addition may be important in the cellular responses that follow electrical activation.
Indexed as
Identifiers
9364049PMC6573615W1848481221What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.